Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/104597
Title: | Liquid Biopsies: Applications for Cancer Diagnosis and Monitoring | Authors: | Martins, Ivana Ribeiro, Ilda Patrícia Jorge, Joana Gonçalves, Ana Cristina Sarmento-Ribeiro, Ana Bela Melo, Joana Barbosa Carreira, Isabel Marques |
Keywords: | cancer; liquid biopsies; diagnosis; prognosis; monitoring; cell-free DNA; circulating tumor cells; precision medicine | Issue Date: | 27-Feb-2021 | Publisher: | MDPI | Serial title, monograph or event: | Genes | Volume: | 12 | Issue: | 3 | Abstract: | The minimally-or non-invasive detection of circulating tumor-derived components in biofluids, such as blood, liquid biopsy is a revolutionary approach with significant potential for the management of cancer. Genomic and transcriptomic alterations can be accurately detected through liquid biopsies, which provide a more comprehensive characterization of the heterogeneous tumor profile than tissue biopsies alone. Liquid biopsies could assist diagnosis, prognosis, and treatment selection, and hold great potential to complement current surveilling strategies to monitor disease evolution and treatment response in real-time. In particular, these are able to detect minimal residual disease, to predict progression, and to identify mechanisms of resistance, allowing to re-orient treatment strategies in a timelier manner. In this review we gathered current knowledge regarding the role and potential of liquid biopsies for the diagnosis and follow-up of cancer patients. The presented findings emphasize the strengths of liquid biopsies, revealing their chance of improving the diagnosis and monitoring of several tumor types in the near future. However, despite growing evidence supporting their value as a management tool in oncology, some limitations still need to be overcome for their implementation in the routine clinical setting. | URI: | https://hdl.handle.net/10316/104597 | ISSN: | 2073-4425 | DOI: | 10.3390/genes12030349 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Liquid-biopsies-Applications-for-cancer-diagnosis-and-monitoringGenes.pdf | 771.96 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
87
checked on Apr 22, 2024
WEB OF SCIENCETM
Citations
81
checked on Apr 2, 2024
Page view(s)
79
checked on Apr 23, 2024
Download(s)
100
checked on Apr 23, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License