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Title: COVID-19 During Development: A Matter of Concern
Authors: Saavedra, Lucas Paulo Jacinto
Prates, Kelly Valério
Gonçalves, Gessica Dutra
Piovan, Silvano
Matafome, Paulo N. 
Mathias, Paulo Cezar de Freitas
Keywords: COVID-19; cardiometabolic disease; SARS-CoV-2; development; metabolic programming; public health
Issue Date: 2021
Publisher: Frontiers Media S.A.
Project: National Council for Scientific and Technological Development (CNPq), Coordination for the Improvement of Higher Education Personnel (CAPES) 
“It’s good to do the good”—JBS 
POCI-01-0145- FEDER-007440 
Serial title, monograph or event: Frontiers in Cell and Developmental Biology
Volume: 9
Abstract: A new infectious disease, COVID-19, has spread around the world. The most common symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are cough and fever, but severe cases can develop acute respiratory distress syndrome. The main receptor for SARS-CoV-2 in human tissue is angiotensin-converting enzyme 2, and the lungs, heart, and kidneys are the most affected organs. Besides the inflammatory process and tissue damage, the presence of a cytokine "storm" has been related to a higher mortality rate. Other infectious viral diseases, such as Zika, chikungunya, and influenza, were associated with complications in pregnant women, such as growth restriction, malformation, preterm birth, low birth weight, miscarriage, and death, although they can also cause developmental disorders in infants and adolescents. Evidence points out that stressors during pregnancy and infancy may lead to the development of obesity, diabetes, and cardiovascular disease. Therefore, we hypothesize that COVID-19 infection during the critical phases of development can program the individual to chronic diseases in adulthood. It is important that COVID-19 patients receive proper monitoring as a way to avoid expensive costs to public health in the future.
ISSN: 2296-634X
DOI: 10.3389/fcell.2021.659032
Rights: openAccess
Appears in Collections:I&D ICBR - Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais

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