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Title: Hepatoprotective Effects of Sweet Cherry Extracts (cv. Saco)
Authors: Gonçalves, Ana C. 
Flores-Félix, José D.
Costa, Ana R. 
Falcão, Amílcar 
Alves, Gilberto 
Silva, Luís R. 
Keywords: antioxidant effects; cytotoxicity; molecular docking; HepG2 cells; sweet cherry phenolics
Issue Date: 29-Oct-2021
Publisher: MDPI
Project: PhD fellowships (2020.04947.BD) 
Marie Skłodowska-Curie grant agreement No 101003373 
Serial title, monograph or event: Foods
Volume: 10
Issue: 11
Abstract: Cancer is the second cause of death worldwide. Among cancers, hepatocellular carcinoma is one of the most prevalent. Evidence indicates that the daily consumption of fruits and vegetables can prevent the onset of various cancers due to the presence of bioactive compounds. Sweet cherries are known for their richness in phenolics, including anthocyanins, which are the major constituents, and presumably, the key contributors to their biological activity. Therefore, the present study aimed to evaluate the effects of three different cherry fractions on human hepatocellular carcinoma (HepG2) cells viability and effectiveness to improve the redox status of these cells under oxidative damage induced by nitric oxide radicals and hydrogen peroxide. Phenolic characterization of fractions was performed by Fourier transform infrared spectroscopy. The obtained results indicated that enriched phenolic fractions of sweet cherries (cv. Saco, can impair cell viability and suppress cells growth after 72 h of exposure, promoting necrosis at the highest tested concentrations (>50 µg/mL). Additionally, fractions also showed the capacity to protect these cells against oxidative injury by capturing radicals before they can attack cells' membrane and by modulating reactive oxygen and nitrogen species generation, as demonstrated by bioinformatic tools.
ISSN: 2304-8158
DOI: 10.3390/foods10112623
Rights: openAccess
Appears in Collections:I&D CIBIT - Artigos em Revistas Internacionais
FFUC- Artigos em Revistas Internacionais

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