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Title: Bioactive Bacterial Nanocellulose Membranes Enriched with Eucalyptus globulus Labill. Leaves Aqueous Extract for Anti-Aging Skin Care Applications
Authors: Almeida, Tânia 
Moreira, Patrícia 
Sousa, Fábio 
Pereira, Cláudia 
Silvestre, Armando J. D. 
Vilela, Carla
Freire, Carmen S. R.
Keywords: bacterial nanocellulose; Eucalyptus globulus Labill. leaves; aqueous extract; antioxidant activity; sheet facial masks; anti-aging; skin care applications
Issue Date: 7-Mar-2022
Project: project CICECO—Aveiro Institute of Materials, UIDB/50011/2020, UIDP/50011/2020, and LA/P/0006/2020, financed by national funds through the FCT/MEC (PIDDAC). 
FCT - CEECIND/00263/2018 
FCT - 2021.01571.CEECIND 
FCT - CEECIND/00464/2017 
Serial title, monograph or event: Materials
Volume: 15
Issue: 5
Abstract: Bacterial nanocellulose (BNC) membranes, with remarkable physical and mechanical properties, emerged as a versatile biopolymeric carrier of bioactive compounds for skin care applications. In this study, BNC membranes were loaded with glycerol (as plasticizer and humectant agent) and different doses (1-3 μg cm-2) of an aqueous extract obtained from the hydro-distillation of Eucalyptus globulus Labill. leaves (HDE), for application as sheet facial masks. All membranes are resistant and highly malleable at dry and wet states, with similar or even better mechanical properties than those of a commercial BNC mask. Moreover, the HDE was found to confer a dose-dependent antioxidant activity to pure BNC. Additionally, upon 3 months of storage at 22-25 °C and 52% relative humidity (RH) or at 40 °C and 75% RH, it was confirmed that the antioxidant activity and the macroscopic aspect of the membrane with 2 μg cm-2 of HDE were maintained. Membranes were also shown to be non-cytotoxic towards HaCaT and NIH/3T3 cells, and the membrane with 2 μg cm-2 of HDE caused a significant reduction in the senescence-associated β-galactosidase activity in NIH/3T3 cells. These findings suggest the suitability and potential of the obtained membranes as bioactive facial masks for anti-aging applications.
ISSN: 1996-1944
DOI: 10.3390/ma15051982
Rights: openAccess
Appears in Collections:I&D CIBB - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais
FFUC- Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais

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