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Title: Lavandula viridis L´Hér. Essential Oil Inhibits the Inflammatory Response in Macrophages Through Blockade of NF-KB Signaling Cascade
Authors: Zuzarte, Mónica da Rocha 
Francisco, Vera
Neves, Bruno
Liberal, Joana
Cavaleiro, Carlos 
Canhoto, Jorge 
Salgueiro, Lígia 
Cruz, Maria Teresa
Keywords: COX-2; IkB; NO; ROS; essentail oil; iNOS; proteasome
Issue Date: 2021
Project: CEF/POCI2010/FEDER 
CEQUIMED-PEst-OE/SAU/ UI4040/2011 
CENTRO-01-0145-FEDER-000012 (HealthyAging 2020) 
Instituto de Salud Carlos III (ISCIII, Spain) 
FEDER - Miguel Servet, Researcher contract to V.F. (CP21/00025) 
Serial title, monograph or event: Frontiers in Pharmacology
Volume: 12
Abstract: Lavandula viridis L´Hér. is an endemic Iberian species with a high essential oil yield and a pleasant lemon scent. Despite these interesting features, this species remains unrecognized and poorly explored by the food and pharmaceutical industries. Nevertheless, it has been valued in traditional medicine being used against flu, circulatory problems and to relieve headaches. Since these disorders trigger inflammatory responses, it is relevant to determine the anti-inflammatory potential of L. viridis L´Hér. essential oil in an attempt to validate its traditional use and concomitantly to increment its industrial exploitation. Therefore, in the present study the chemical composition of this volatile extract as well as the effect on ROS production, inflammatory response and proteasome activity on LPS-stimulated macrophages were disclosed. Also, its safety profile on keratinocytes, hepatocytes and alveolar epithelial cells was depicted, envisioning a future human administration. The essential oil was characterized by high quantities of 1,8-cineole, camphor and α-pinene. From a pharmacological point of view, the essential oil showed a potent antioxidant effect and inhibited nitric oxide production through down-modulation of nuclear factor kappa B-dependent Nos2 transcription and consequently iNOS protein expression as well as a decrease in proteasomal activity. The anti-inflammatory activity was also evidenced by a strong inhibition of LPS-induced Il1b and Il6 transcriptions and downregulation of COX-2 levels. Overall, bioactive safe concentrations of L. viridis L´Hér. essential oil were disclosed, thus corroborating the traditional usage of this species and paving the way for the development of plant-based therapies.
ISSN: 1663-9812
DOI: 10.3389/fphar.2021.695911
Rights: openAccess
Appears in Collections:I&D ICBR - Artigos em Revistas Internacionais
FFUC- Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais

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