Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/103217
Title: Shaping of Hepatic Ischemia/Reperfusion Events: The Crucial Role of Mitochondria
Authors: Teodoro, João S. 
Silva, Rui T. da 
Machado, Ivo 
Panisello-Roselló, Arnau
Roselló-Catafau, Joan 
Rolo, Anabela P. 
Palmeira, Carlos M. 
Keywords: mitochondria; liver; ischemia/reperfusion; liver surgery; conditioning
Issue Date: 2022
Project: UIDB/04539/2020 
UIDP/04539/2020 
CEEC researcher grant from FCT and CNC - CEECIND/4400/2007 
FCT - PhD scholarship (DFA/BD/8529/2020) 
Foie Gras Early Research Training Grant, from the European Union’s Horizon 2020 Research and Innovation programme under the Marie Sklodowska-Curie Grant (Agreement No. 722619) 
Serial title, monograph or event: Cells
Volume: 11
Issue: 4
Abstract: Hepatic ischemia reperfusion injury (HIRI) is a major hurdle in many clinical scenarios, including liver resection and transplantation. Various studies and countless surgical events have led to the observation of a strong correlation between HIRI induced by liver transplantation and early allograft-dysfunction development. The detrimental impact of HIRI has driven the pursuit of new ways to alleviate its adverse effects. At the core of HIRI lies mitochondrial dysfunction. Various studies, from both animal models and in clinical settings, have clearly shown that mitochondrial function is severely hampered by HIRI and that its preservation or restoration is a key indicator of successful organ recovery. Several strategies have been thus implemented throughout the years, targeting mitochondrial function. This work briefly discusses some the most utilized approaches, ranging from surgical practices to pharmacological interventions and highlights how novel strategies can be investigated and implemented by intricately discussing the way mitochondrial function is affected by HIRI.
URI: https://hdl.handle.net/10316/103217
ISSN: 2073-4409
DOI: 10.3390/cells11040688
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
IIIUC - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais

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