Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/102116
DC FieldValueLanguage
dc.contributor.authorCristo, Fernando-
dc.contributor.authorInácio, José M-
dc.contributor.authorRosas, Graça-
dc.contributor.authorCarreira, Isabel Marques-
dc.contributor.authorMelo, Joana Barbosa-
dc.contributor.authorAlmeida, Luís Pereira de-
dc.contributor.authorMendes, Patrícia-
dc.contributor.authorMartins, Duarte Saraiva-
dc.contributor.authorMaio, José-
dc.contributor.authorAnjos, Rui-
dc.contributor.authorBelo, José A.-
dc.date.accessioned2022-09-26T10:58:20Z-
dc.date.available2022-09-26T10:58:20Z-
dc.date.issued2017-
dc.identifier.issn18735061pt
dc.identifier.urihttps://hdl.handle.net/10316/102116-
dc.description.abstractA human iPSC line was generated from exfoliated renal epithelial (ERE) cells of a patient affected with Congenital Heart Disease (CHD) and Laterality Defects carrying tshe variant p.R152H in the DAND5 gene. The transgene-free iPSCs were generated with the human OSKM transcription factor using the Sendai-virus reprogramming system. The established iPSC line had the specific heterozygous alteration, a stable karyotype, expressed pluripotency markers and generated embryoid bodies that can differentiate towards the three germ layers in vitro. This iPSC line offers a useful resource to study the molecular mechanisms of cardiomyocyte proliferation, as well as for drug testing.pt
dc.language.isoengpt
dc.relationPTDC/BIM-MED/3363/2014pt
dc.relationiNOVA4Health - UID/Multi/04462/2013pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt
dc.subject.meshCell Differentiationpt
dc.subject.meshCell Linept
dc.subject.meshCellular Reprogrammingpt
dc.subject.meshChildpt
dc.subject.meshEmbryoid Bodiespt
dc.subject.meshHeart Defects, Congenitalpt
dc.subject.meshHumanspt
dc.subject.meshInduced Pluripotent Stem Cellspt
dc.subject.meshIntercellular Signaling Peptides and Proteinspt
dc.subject.meshKaryotypept
dc.subject.meshMalept
dc.subject.meshMutation, Missensept
dc.titleGeneration of human iPSC line from a patient with laterality defects and associated congenital heart anomalies carrying a DAND5 missense alterationpt
dc.typearticle-
degois.publication.firstPage152pt
degois.publication.lastPage156pt
degois.publication.titleStem Cell Researchpt
dc.peerreviewedyespt
dc.identifier.doi10.1016/j.scr.2017.10.019pt
degois.publication.volume25pt
dc.date.embargo2017-01-01*
uc.date.periodoEmbargo0pt
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.openairetypearticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCIBB - Center for Innovative Biomedicine and Biotechnology-
crisitem.author.orcid0000-0001-6842-1707-
crisitem.author.orcid0000-0001-5831-3307-
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais
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