Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/102116
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cristo, Fernando | - |
dc.contributor.author | Inácio, José M | - |
dc.contributor.author | Rosas, Graça | - |
dc.contributor.author | Carreira, Isabel Marques | - |
dc.contributor.author | Melo, Joana Barbosa | - |
dc.contributor.author | Almeida, Luís Pereira de | - |
dc.contributor.author | Mendes, Patrícia | - |
dc.contributor.author | Martins, Duarte Saraiva | - |
dc.contributor.author | Maio, José | - |
dc.contributor.author | Anjos, Rui | - |
dc.contributor.author | Belo, José A. | - |
dc.date.accessioned | 2022-09-26T10:58:20Z | - |
dc.date.available | 2022-09-26T10:58:20Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 18735061 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/102116 | - |
dc.description.abstract | A human iPSC line was generated from exfoliated renal epithelial (ERE) cells of a patient affected with Congenital Heart Disease (CHD) and Laterality Defects carrying tshe variant p.R152H in the DAND5 gene. The transgene-free iPSCs were generated with the human OSKM transcription factor using the Sendai-virus reprogramming system. The established iPSC line had the specific heterozygous alteration, a stable karyotype, expressed pluripotency markers and generated embryoid bodies that can differentiate towards the three germ layers in vitro. This iPSC line offers a useful resource to study the molecular mechanisms of cardiomyocyte proliferation, as well as for drug testing. | pt |
dc.language.iso | eng | pt |
dc.relation | PTDC/BIM-MED/3363/2014 | pt |
dc.relation | iNOVA4Health - UID/Multi/04462/2013 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt |
dc.subject.mesh | Cell Differentiation | pt |
dc.subject.mesh | Cell Line | pt |
dc.subject.mesh | Cellular Reprogramming | pt |
dc.subject.mesh | Child | pt |
dc.subject.mesh | Embryoid Bodies | pt |
dc.subject.mesh | Heart Defects, Congenital | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Induced Pluripotent Stem Cells | pt |
dc.subject.mesh | Intercellular Signaling Peptides and Proteins | pt |
dc.subject.mesh | Karyotype | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Mutation, Missense | pt |
dc.title | Generation of human iPSC line from a patient with laterality defects and associated congenital heart anomalies carrying a DAND5 missense alteration | pt |
dc.type | article | - |
degois.publication.firstPage | 152 | pt |
degois.publication.lastPage | 156 | pt |
degois.publication.title | Stem Cell Research | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1016/j.scr.2017.10.019 | pt |
degois.publication.volume | 25 | pt |
dc.date.embargo | 2017-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CIBB - Center for Innovative Biomedicine and Biotechnology | - |
crisitem.author.orcid | 0000-0001-6842-1707 | - |
crisitem.author.orcid | 0000-0001-5831-3307 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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1-s2.0-S1873506117302234-main.pdf | 709.18 kB | Adobe PDF | View/Open |
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