Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/101617
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Luther, Bethala Jawahar | - |
dc.contributor.author | Rani, Chekuri Sharmila | - |
dc.contributor.author | Suresh, Namburi | - |
dc.contributor.author | Basaveswara Rao, Mandava V. | - |
dc.contributor.author | Kapavarapu, Ravikumar | - |
dc.contributor.author | Suresh, Chakali | - |
dc.contributor.author | Vijaya Babu, P. | - |
dc.contributor.author | Pal, Manojit | - |
dc.date.accessioned | 2022-09-02T11:41:17Z | - |
dc.date.available | 2022-09-02T11:41:17Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 18785352 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/101617 | - |
dc.description.abstract | A series of novel hybrid molecules were designed rationally by connecting an indole moiety with a quinoxaline ring through a linker as potential inhibitors of PDE4. Their design was validated initially in silico by performing docking studies using a representative molecule. Subsequent synthesis of a focused library of related hybrid molecules was accomplished using Pd/CACu mediated coupling-cyclization as a key step. Some of the synthesized compounds showed PDE4 inhibition in vitro and one of them appeared to be promising. | pt |
dc.language.iso | eng | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt |
dc.subject | Indole | pt |
dc.subject | Quinoxaline | pt |
dc.subject | Pd/C | pt |
dc.subject | PDE4 | pt |
dc.title | Design and synthesis of novel indole-quinoxaline hybrids to target phosphodiesterase 4 (PDE4) | pt |
dc.type | article | - |
degois.publication.firstPage | 3108 | pt |
degois.publication.lastPage | 3117 | pt |
degois.publication.issue | 8 | pt |
degois.publication.title | Arabian Journal of Chemistry | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1016/j.arabjc.2015.08.009 | pt |
degois.publication.volume | 12 | pt |
dc.date.embargo | 2019-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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1-s2.0-S187853521500249X-main.pdf | 1.08 MB | Adobe PDF | View/Open |
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