Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/101533
Título: | Safe-by-design development of a topical patch for drug delivery | Autor: | Vaz, Mafalda B. Vitorino, Carla Sousa, João J. S. |
Palavras-chave: | Topical patches; Ibuprofen; Mechanical properties; Permeation studies; Safe-by-design | Data: | 2020 | Projeto: | project PEst-UID/NEU/04539/2013 COMPETE (Ref. POCI-01-0145-FEDER-007440) Research Project n.º 016648 (Ref. PTDC/CTMNAN/ 2658/2014) |
Título da revista, periódico, livro ou evento: | Brazilian Journal of Pharmaceutical Sciences | Volume: | 56 | Resumo: | Few topical products have been developed specifically to treat acute and chronic arthritis and inflammation, using non-steroidal anti-inflammatory drugs (NSAIDs). The lack of dosing accuracy commonly found in locally applied semisolid products for cutaneous use is a critical issue that leads to treatment failure. The aim of the present work is to develop a differentiated and innovative topical patch based on a monolithic hydrogel for ibuprofen skin delivery, in order to provide a safer and accurate way of drug administration along with improved treatment compliance. Topical patches based on hydroxypropylmethylcellulose (HPMC) were optimized in composition, in terms of enhancer and adhesive, supported on a systematic assessment of in vitro release and permeation behavior and adhesion properties. Several mathematical models were used to scrutinize the release mechanisms from the patches. In vitro release kinetics was shown to be mainly driven by diffusion. However, other mechanisms seemed to be also present, supporting the feasibility of using patches for sustained drug delivery. PEG 200 provided the best permeation rate, with a permeation enhancement ratio of ca. 3 times higher, than the commercial reference. The addition of Eudragit L30D 55 to the formulation led to the best adhesion profile, thus achieving a successful development based on a safe-by-design concept. | URI: | https://hdl.handle.net/10316/101533 | ISSN: | 2175-9790 | DOI: | 10.1590/s2175-97902020000118629 | Direitos: | openAccess |
Aparece nas coleções: | FFUC- Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Safebydesign-development-of-a-topical-patch-for-drug-deliveryBrazilian-Journal-of-Pharmaceutical-Sciences.pdf | 765.09 kB | Adobe PDF | Ver/Abrir |
Visualizações de página
75
Visto em 28/ago/2024
Downloads
134
Visto em 28/ago/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Este registo está protegido por Licença Creative Commons