Please use this identifier to cite or link to this item:
Title: De novo colorectal cancer after liver and kidney transplantation–Microenvironment disturbance
Authors: Oliveira, Rui Caetano 
Silva, Edgar Tavares da 
Abrantes, Ana Margarida 
Antunes, Hugo 
Teixeira, Paulo
Gomes, Ana
Martins, Ricardo 
Furtado, Emanuel 
Figueiredo, Arnaldo 
Costa, Beatriz 
Cipriano, Maria Augusta 
Tralhão, José Guilherme 
Botelho, Maria Filomena 
Keywords: Colorectal cancer; Tumour microenviroenment; Transplantation
Issue Date: 2020
Serial title, monograph or event: Transplantation Reports
Volume: 5
Issue: 3
Abstract: Colorectal cancer (CRC) is a major health burden and may arise as a complication of solid organ transplantation. Our study aimed to assess the incidence of the CRC in kidney and liver transplanted patients at a tertiary and reference center and to describe their clinical and pathological features. Twelve patients, 10 men and two women, with a mean age of 60 years, composed our cohort, ten of them submitted to CRC resection. Transplanted organ was liver in five patients and kidney in seven. Regarding overall survival, patients submitted to renal transplantation were all deceased 5 years after CRC diagnosis, while those subjected to hepatic transplantation had a survival of 60% at the fifth year. Pathology examination showed seven patients with advanced disease (stage III/IV) and high amount of necrosis. Tumor microenvironment was disturbed, with low inflammatory infiltrate, absence of natural killer cells and no PD-L1 expression. CRC exhibited microsatellite instability in 40%, with expression of cancer stem cell markers (CD133, CD44 and ALDH1), as well as P53 (50%) and KRAS mutations (41.7%). CRC cancer after kidney and hepatic transplantation is a rare, but aggressive and deadly event. Regular follow-up should be instituted in these patients.
ISSN: 24519596
DOI: 10.1016/j.tpr.2020.100057
Rights: openAccess
Appears in Collections:I&D ICBR - Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
1-s2.0-S2451959620300196-main.pdf1.38 MBAdobe PDFView/Open
Show full item record

Page view(s)

checked on Sep 25, 2023


checked on Sep 25, 2023

Google ScholarTM




This item is licensed under a Creative Commons License Creative Commons