Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/101134
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Santos, Telmo N. | - |
dc.contributor.author | Costa, Gustavo | - |
dc.contributor.author | Ferreira, J. Pinto | - |
dc.contributor.author | Liberal, Joana | - |
dc.contributor.author | Francisco, Vera | - |
dc.contributor.author | Paranhos, António | - |
dc.contributor.author | Cruz, Maria T. | - |
dc.contributor.author | Castelo-Branco, M. | - |
dc.contributor.author | Figueiredo, I. Vitória | - |
dc.contributor.author | Batista, M. Teresa | - |
dc.date.accessioned | 2022-08-10T15:28:58Z | - |
dc.date.available | 2022-08-10T15:28:58Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://hdl.handle.net/10316/101134 | - |
dc.description.abstract | Agrimony (Agrimonia eupatoria L.) (Ae) is used in traditional medicine to treat inflammatory and oxidative related diseases. T herefore, this study focuses on the anti-inflammatory and analgesic potential of Ae infusion (AeI). Phenolic compounds characterization was achieved by HPLC-PDA-ESI/MSn. To evaluate antioxidant potential, 2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide anion, hydroxyl radical, and SNAP assays were used. In vitro anti-inflammatory activity of AeI was investigated in LPS-stimulated macrophages by measuring the NO production. In vivo anti-inflammatory activity was validated using the mouse carrageenan-induced paw edema model. Peripheral and central analgesic potential was evaluated using the acetic acid-induced writhing and hot-plate tests, respectively, as well as the formalin assay to assess both activities. The safety profile was disclosed in vitro andinvivo, usingMTTandhematoxylinassays,respectively.Vitexin,quercetin O-galloyl-hexoside, andkaempferol O-acetylhexosyl-rhamnoside were referred to in this species for the first time. AeI and mainly AePF (Ae polyphenolic fraction) showed a significant antiradical activity against all tested radicals. Both AeI and AePF decreased NO levels in vitro, AePF being more active than AeI. In vivo anti-inflammatory and analgesic activities were verified for both samples at concentrations devoid of toxicity. Agrimony infusion and, mainly, AePF are potential sources of antiradical and anti-inflammatory polyphenols. | pt |
dc.description.sponsorship | T he authors acknowledge “Segredo da Planta” for the plant provided to Célia Cabral, Ph.D., for the plant identification and Node CEF/UC, integrated in the National Mass Spectrometry Network (RNEM) of Portugal, for MS analyses. Research is supported by FEDER/COMPETE (FCOMP01-0124-FEDER-011096) and FCT, by Projects PTDC/SAUFCF/105429/2008 and PEst-OE/SAU/UI0177/2011. | pt |
dc.language.iso | eng | pt |
dc.publisher | Hindawi | pt |
dc.relation | PTDC/SAU-FCF/105429/2008 | pt |
dc.relation | FCOMP-01-0124-FEDER-011096 | pt |
dc.relation | PEst-OE/SAU/UI0177/2011 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.title | Antioxidant, Anti-Inflammatory, and Analgesic Activities of Agrimonia eupatoria L. Infusion | pt |
dc.type | article | en_US |
degois.publication.firstPage | 1 | pt |
degois.publication.lastPage | 13 | pt |
degois.publication.issue | 8309894 | pt |
degois.publication.title | Evidence-Based Complementary and Alternative Medicine | pt |
dc.date.updated | 2022-07-30T23:09:58Z | - |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1155/2017/8309894 | pt |
degois.publication.volume | 2017 | pt |
dc.description.version | 3910-3178-31BA | MARIA MARGARIDA COUTINHO DE SEABRA CASTEL-BRANCO CAETANO | - |
dc.description.version | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.slug | cv-prod-144165 | - |
dc.date.embargo | 2017-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CIBIT - Coimbra Institute for Biomedical Imaging and Translational Research | - |
crisitem.author.orcid | 0000-0003-4364-6373 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FFUC- Artigos em Revistas Internacionais I&D CIBIT - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
RIt-24_Antioxidant__Anti-Inflammatory__and_Analgesic_Activities_of_Agrimonia_eupatoria_L._Infusion_2017.pdf | 2.71 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License