Please use this identifier to cite or link to this item:
Title: Hepatic and renal toxicities of indomethacin acid, salt form and complexed forms with hydroxypropyl-ß-cyclodextrin on Wistar rats after oral administration
Authors: Ribeiro-Rama, Ana Cristina
Figueiredo, Isabel Vitória 
Veiga, Francisco José 
Castel-Branco, M. M. 
Cabrita, António M. Silvério 
Caramona, Margarida 
Keywords: histopathology; hydroxypropylb-cyclodextrin; indomethacin; kidney; liver; toxicity
Issue Date: 2011
Publisher: Société Française de Pharmacologie et de Thérapeutique
Serial title, monograph or event: Fundamental & Clinical Pharmacology
Volume: 25
Issue: 5
Abstract: Indomethacin (IM), a non-steroidal anti-inflammatory drug, has the capacity to induce hepatic and renal injuries when administrated systemically. The aim of this study is to assess the IM absorption from complexed forms when orally administered to rats, by means of a comparative evaluation of its capacity to induce hepatic and renal injury in different forms, namely IM acid, IM sodium salt or IM complexed with hydroxypropyl-b-cyclodextrin (HP-b-CD), using freeze- and spray-drying methods. Atotal of 135 Wistar rats weighing 224.4 ± 62.5 g were put into 10 groups. They were allowed free access to water but were maintained on fast for 18 h before the first administration until the end of the experiment. Water and HP-b-CD (control groups) and IM acid form, IM trihydrated-sodium-salt and IM-HP-b-CD spray- and freezedried, at normal and toxic doses (test groups), were orally administered once/day for 3 days. Seventy-two hours after the first administration, the animals were sacrificed and a fragment of the liver and one kidney were collected and prepared for histopathological evaluation. Lesion indexes (rated 0/4 for liver and 0/3 for kidney) were developed and the type of injury scored according to the severity of damage. A statistical analysis of the severity and incidence of lesions was carried out. Animals administered with IM complexed forms showed similar hepatic and renal lesions, both in toxic and therapeutic doses, when compared with those observed in animals administered with IM acid or salt forms. This suggests that under the present experimental conditions, IM is equally absorbed from the gastrointestinal tract, independently of the administered IM form.
DOI: 10.1111/j.1472-8206.2010.00887.x
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais

Show full item record


checked on Nov 17, 2022


checked on May 2, 2023

Page view(s)

checked on Oct 2, 2023


checked on Oct 2, 2023

Google ScholarTM




This item is licensed under a Creative Commons License Creative Commons