Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/101116
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Rama, A. C. | - |
dc.contributor.author | Figueiredo, Isabel Vitoria | - |
dc.contributor.author | Veiga, F. | - |
dc.contributor.author | Castel-Branco, M. M. | - |
dc.contributor.author | Cabrita, A. M. S. | - |
dc.contributor.author | Caramona, M. M. | - |
dc.date.accessioned | 2022-08-10T15:24:40Z | - |
dc.date.available | 2022-08-10T15:24:40Z | - |
dc.date.issued | 2009 | - |
dc.identifier.uri | https://hdl.handle.net/10316/101116 | - |
dc.description.abstract | Indomethacin (IM) is a non-steroidal anti-inflammatory drug which inhibits prostaglandin biosynthesis. It is practically insoluble in water and has the capacity to induce gastric injury. Hydroxypropyl-b-cyclodextrin (HP-b-CD) is an alkylated derivative of b-CD with the capacity to form inclusion complexes with suitable molecules. IM is considered to form partial inclusion complexes with HP-b-CD by enclosure of the p-chlorobenzoic part of the molecule in the cyclodextrin channel, reducing the adverse effects. The aim of this paper is to evaluate the gastric damage induced by the IM inclusion complex prepared by freeze-drying and spray-drying. A total of 135 Wistar rats weighing 224.4 ± 62.5 g were put into 10 groups. They were allowed free access to water but were maintained fasted for 18 h before the first administration until the end of the experiment. IM acid-form, IM trihydrated-sodiumsalt and IM-HP-b-CD spray and freeze-dried, at normal and toxic doses, were administered through gastric cannula once/day for 3 days. Seventy-two hours after the first administration, the animals were sacrificed and the stomachs collected and prepared for morphological study by using the haematoxylin-eosin technique. Lesion indexes (rated 0/4) were developed and the type of injury was scored according to the severity of damage and the incidence of microscopic evidence of harm. Microscopic assessment demonstrated levels of injury with index one on 10–25%. The type of complexation method had different incidence but the same degree. The results show that IM inclusion complexation protects against gastric injury, reducing the incidence and the maximum degree of severity from 4 to 1, with a better performance of the spray-dried complex. | pt |
dc.language.iso | eng | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | freeze-dried | pt |
dc.subject | gastric injury | pt |
dc.subject | histopathologic analysis | pt |
dc.subject | hydroxypropyl-b-cyclodextrin complex | pt |
dc.subject | indomethacin | pt |
dc.subject | spray-dried | pt |
dc.title | Evaluation of gastric toxicity of indomethacin acid, salt form and complexed forms with hydroxypropyl-beta-cyclodextrin on Wistar rats: histopathologic analysis | pt |
dc.type | article | en_US |
degois.publication.firstPage | 747 | pt |
degois.publication.lastPage | 755 | pt |
degois.publication.issue | 6 | pt |
degois.publication.title | Fundamental & Clinical Pharmacology | pt |
dc.date.updated | 2022-07-30T22:25:48Z | - |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1111/j.1472-8206.2009.00718.x | pt |
degois.publication.volume | 23 | pt |
dc.description.version | 3910-3178-31BA | MARIA MARGARIDA COUTINHO DE SEABRA CASTEL-BRANCO CAETANO | - |
dc.description.version | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.slug | cv-prod-143881 | - |
dc.date.embargo | 2009-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | https://orcid.org/0000-0003-0127-4575 | - |
crisitem.author.orcid | 0000-0002-6116-1479 | - |
crisitem.author.orcid | 0000-0002-6533-9932 | - |
crisitem.author.orcid | 0000-0001-5165-5849 | - |
crisitem.author.orcid | 0000-0003-1950-9360 | - |
Aparece nas coleções: | FFUC- Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
RIt-13_Evaluation_of_gastric_toxicity_of_indomethacin_acid__salt_form_and_complexed_forms_2009.pdf | 316.37 kB | Adobe PDF | Ver/Abrir |
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