Projetos Estatísticas: This work has been supported by a Diabetes UK RD Lawrence Fellowship (14/0005128) (QZ) and an EFSD New Targets for Diabetes or Obesityrelated Metabolic Diseases Programme (QZ), the Swedish Foundation for Strategic Research (IRC-LUDC; AW), the Swedish Research Council (SFOEXODIAB; AW), the Albert Påhlsson Foundation (AW), and National Natural Science Foundation of China (82200887) (RG).

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