Project Statistics: This paper was financially supported by the Fundação para a Ciência e a Tecnologia (FCT), Portuguese Agency for Scientific Research, through: the project no. 016648 (Ref. POCI-01-0145-FEDER-016648), the project PEst-UID/NEU/04539/2013, and COMPETE (Ref. POCI-01-0145-FEDER-007440)-Center for Neurosciences and Cell Biology (CNC); the projects PEst-OE/QUI/UI0313/2014 and POCI-01-0145-FEDER-007630-Coimbra Chemistry Centre; and the project UID/QUI/50006/2013-LAQV/REQUIMTE. Tânia Cova acknowledges the PhD research grant SFRH/BD/95459/2013, assigned by FCT.

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