This research was funded by STEM@REST Project (CENTRO-01-0145-FEDER-028871) and by European Regional Development Fund (ERDF), through Centro 2020 Regional Operational Programme project CENTRO-01-0145-FEDER-000012-HealthyAging2020; COMPETE 2020—Operational Programme for Competitiveness and Internationalisation; and the Portuguese national funds via Fundação para a Ciência e a Tecnologia (FCT), I.P. project POCI-01-0145-FEDER-007440. M.S. and M.M.P. were funded by Fundação para a Ciência e Tecnologia (FCT) Portugal, under research grant references 2020.06180.BD and 2022.11089.BD, respectively. Strategic Research Centre Project of CIEPQPF was funded by FCT (UIDB00102/2020). This research was also funded by Fundação para a Ciência e Tecnologia, Strategic Research Centre Project (UIDB/00102/2020). Part of the project was also funded by Merck SA.