Open access funding provided by FCT|FCCN (b-on). This work was supported by the project GLOBALED (PTDC/BIAECO/ 30552/2017), co-financed by COMPETE 2020, Portugal 2020 and the European Union through the ERDF and by FCT through national funds. PG Cardoso (IF/01506/2014) was supported by FCT investigator contract, subsidized by the European Social Fund and MCTES (Portuguese Ministry of Science, Technology and Higher Education), through the POPH (Human Potential Operational Program) and Hugo Morais by a FCT PhD grant (SFRH/BD/139762/2018). This research was also supported by national funds through FCT — Foundation for Science and Technology within the scope of UIDB/04423/2020, UID/ BIA/04004/2013 and UIDP/04423/2020. Additional support was also obtained via CENTRO-01–0145-FEDER-000007, funded by the Comissão de Coordenação da Região Centro (CCDR-C) and subsidized by the European Regional Development Fund (FEDER).