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The authors are grateful to Fundação para a Ciência e a Tecnologia (Lisbon, Portugal) for the PhD fellowship of Paulo Magalhães (SFRH/BD/85069/2012), involving the POPH– QREN, which is co-funded by FSE and MEC. The authors also acknowledge the support provided by FEDER funds through the POCI - COMPETE 2020 - Operational Programme Competitiveness and Internationalisation in Axis I - Strengthening research, technological development and innovation (Project No. 007491) and National Funds by FCT - Foundation for Science and Technology (Project UID/Multi /00709). This study was also partially supported (FdA) by Instituto de Salud Carlos III-Sara Borrell program (CD13/00348, Spain).