PhD scholarships attributed to T.P. (SFRH/BD/ 51684/2011), M.C. (SFRH/BD/51681/2011), and M.I.S. (SFRH/ BD/86260/2012) and a postdoc fellowship attributed to S.P. (SFRH/BPD/98995/2013). Center for Neuroscience and Cell Biology (CNC) is also funded by FCT under the strategic project UID/NEU/04539/2013. The authors also give thanks for the grant support by FCT and FEDER/COMPETE 2020 (POCI-01-0145- FEDER-007440) and HealthyAging2020:CENTRO-01-0145- FEDER-000012.