Supported by: The Portuguese Foundation for Science and Technology (FCT) (Projects: PTDC/SAU-NEU/103728/2008, PTDC/NEU-NMC/0205/2012, UID/NEU/04539/2013; Post- Doc grants: SFRH/BPD/78187/2011-JC, SFRH/BD/88419/2012-CS and SFRH/BD/80577/2011-MM; and the Investigator Programme: IF/00638/2014. IPATIMUP is an Associate Laboratory of the Portuguese Ministry of Science, Technology and Higher Education and is partially supported by FCT. This work was co-financed by FEDER - Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT—Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Inovação in the framework of the project “Institute for Research and Innovation in Health Sciences” (POCI-01–0145- FEDER-007274). This work also had the financial support of FCT / MEC through National Funds and, when applicable, co-financed by the FEDER via the PT2020 Partnership Agreement under the 4293 Unit I&D. Last but not least, it was also financed by QREN (Quadro de Referência Estratégica Nacional) and by The National Mass Spectrometry Network (RNEM) (REDE/1506/REM/2005).