I.S. and L.P. are holders of Portuguese Foundation for Science and Technology (FCT) Investigator grants (IF/01799/2013 and IF/01079/2014, respectively). C.D. is a recipient of PhD fellowship of PhDOC program. P.P. and E.F. hold FCT postdoc fellowships. This work was funded by FCT research grants “PTDC/SAUNMC/ 113934/2009” (to I.S.), the Portuguese North Regional Operational Program (ON.2) under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER), the Project Estratégico co-funded by FCT (PEst-C/SAU/LA0026/2013), and the European Regional Development Fund COMPETE (FCOMP-01-0124-FEDER-037298) as well as the project NORTE-01-0145-FEDER-000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER).