This work was financed by the European Regional Development Fund (ERDF) through the COMPETE 2020 – Operational Programme for Competitiveness and Internationalisation and Portuguese national funds via FCT – Fundação para a Ciência e a Tecnologia, I.P., under projects: PTDC/NEU-NMC/0205/2012, POCI-01-0145-FEDER-007440 (ref.; UID/NEU/04539/2013), POCI-01-0145-FEDER-016428 (ref.: SAICTPAC/0010/2015), POCI-01-0145-FEDER-016795 (ref.: PTDC/ NEU-SCC/7051/2014), POCI-01-0145-FEDER-029311 (ref.: PTDC/ BTM-TEC/29311/2017), POCI-01-0145-FEDER-30943 (ref.: PTDC/ MEC-PSQ/30943/2017) and PTDC/MED-NEU/27946/2017; and by The National Mass Spectrometry Network (RNEM) under the contract POCI-01-0145-FEDER-402-022125 (ref.: ROTEIRO/0028/2013). S.I.A, was supported by Ph.D. fellowship SFRH/BD/81495/2011, co-financed by the European Social Fund (ESF) through the POCH – Programa Operacional do Capital Humano and national funds via FCT.