This work was funded by Santa Casa da Misericórdia de Lisboa, Portugal through Mantero Belard Neurosciences Prize 2016 (MB-40-2016); by the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme under project CENTRO-01-0145-FEDER-000012 (HealthyAging2020) and through the COMPETE 2020—Operational Programme for Competitiveness and Internationalisation and Portuguese national funds via FCT—Fundação para a Ciência e a Tecnologia, under project POCI01-0145- FEDER-030712. We are indebted to the IDIBAPS Biobank and to Professor I Ferrer Abizanda, Bellvitge Hospital Universitari, Institut Català de la Salut, Barcelona, Spain for sample and data procurement. The mass spectrometry technique was performed at the i3S Proteomics Scientific Platform with the assistance of Hugo Osório, supported from the Portuguese Mass Spectrometry Network, integrated in the National Roadmap of Research Infrastructures of Strategic Relevance (ROTEIRO/0028/2013; LISBOA-01-0145-FEDER-022125).