This work was supported by funds from FEDER through COMPETE program and Fundação para a Ciência e a Tecnologia (FCT) (EXPL/DTP-FTO/0570/2012, MITPTB/ ECE/0013/2013 to S. R. and L.F., and PTDC/SAU-ENB/113696/2009 to R.P.N.; SFRH/BD/51197/2010 and SFRH/BPD/79323/2011 to P.G. and S.R., respectively) as well as COMPETE program for the project “Stem cell based platforms for Regenerative and Therapeutic Medicine” (Centro-07-ST24-FEDER-002008). The authors also would like to acknowledge the help of Tommaso Mazzochi for the finite model simulations.

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This work was supported by funds from FEDER through COMPETE program and Fundação para a Ciência e a Tecnologia (FCT) (EXPL/DTP-FTO/0570/2012, MITPTB/ ECE/0013/2013 to S. R. and L.F., and PTDC/SAU-ENB/113696/2009 to R.P.N.; SFRH/BD/51197/2010 and SFRH/BPD/79323/2011 to P.G. and S.R., respectively) as well as COMPETE program for the project “Stem cell based platforms for Regenerative and Therapeutic Medicine” (Centro-07-ST24-FEDER-002008). The authors also would like to acknowledge the help of Tommaso Mazzochi for the finite model simulations.