Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/99647
DC FieldValueLanguage
dc.contributor.authorSalazar, Ivan L.-
dc.contributor.authorLourenço, Ana S. T.-
dc.contributor.authorManadas, Bruno-
dc.contributor.authorBaldeiras, Inês-
dc.contributor.authorFerreira, Cláudia-
dc.contributor.authorTeixeira, Anabela Claro-
dc.contributor.authorMendes, Vera M.-
dc.contributor.authorNovo, Ana Margarida-
dc.contributor.authorMachado, Rita-
dc.contributor.authorBatista, Sónia-
dc.contributor.authorMacário, Maria do Carmo-
dc.contributor.authorGrãos, Mário-
dc.contributor.authorSousa, Lívia-
dc.contributor.authorSaraiva, Maria João-
dc.contributor.authorPais, Alberto A. C. C.-
dc.contributor.authorDuarte, Carlos B.-
dc.date.accessioned2022-04-05T04:42:43Z-
dc.date.available2022-04-05T04:42:43Z-
dc.date.issued2022-02-08-
dc.identifier.issn1742-2094pt
dc.identifier.urihttps://hdl.handle.net/10316/99647-
dc.description.abstractMultiple sclerosis is an inflammatory and degenerative disease of the central nervous system (CNS) characterized by demyelination and concomitant axonal loss. The lack of a single specific test, and the similarity to other inflammatory diseases of the central nervous system, makes it difficult to have a clear diagnosis of multiple sclerosis. Therefore, laboratory tests that allows a clear and definite diagnosis, as well as to predict the different clinical courses of the disease are of utmost importance. Herein, we compared the cerebrospinal fluid (CSF) proteome of patients with multiple sclerosis (in the relapse-remitting phase of the disease) and other diseases of the CNS (inflammatory and non-inflammatory) aiming at identifying reliable biomarkers of multiple sclerosis.pt
dc.description.sponsorshipThis work was fnanced by the National Multiple Sclerosis Society (USA) (RG-1601-07502), Biogen and by grants from the Portuguese Science and Technology Foundation (FCT), the European Regional Development Fund (ERDF)pt
dc.language.isoengpt
dc.publisherBMCpt
dc.relationBrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologiaspt
dc.relationUIDB/04539/2020pt
dc.relationUIDP/04539/2020pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subjectBiomarkerspt
dc.subjectCerebrospinal fluid (CSF)pt
dc.subjectMultiple sclerosispt
dc.subjectTransthyretin (TTR)pt
dc.titlePosttranslational modifications of proteins are key features in the identification of CSF biomarkers of multiple sclerosispt
dc.typearticle-
degois.publication.firstPage44pt
degois.publication.issue1pt
degois.publication.titleJournal of Neuroinflammationpt
dc.peerreviewedyespt
dc.identifier.doi10.1186/s12974-022-02404-2pt
degois.publication.volume19pt
dc.date.embargo2022-02-08*
uc.date.periodoEmbargo0pt
item.openairetypearticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextCom Texto completo-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCenter for Research in Neuropsychology and Cognitive Behavioral Intervention-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0002-2087-4042-
crisitem.author.orcid0000-0002-8106-7308-
crisitem.author.orcid0000-0002-7020-9606-
crisitem.author.orcid0000-0002-4593-673X-
crisitem.author.orcid0000-0002-6081-6955-
crisitem.author.orcid0000-0002-2707-1488-
crisitem.author.orcid0000-0002-6725-6460-
crisitem.author.orcid0000-0002-1474-0208-
crisitem.project.grantnoCENTRO-01-0145-FEDER-000008-
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
FCTUC Química - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais
IIIUC - Artigos em Revistas Internacionais
FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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