Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/99647
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Salazar, Ivan L. | - |
dc.contributor.author | Lourenço, Ana S. T. | - |
dc.contributor.author | Manadas, Bruno | - |
dc.contributor.author | Baldeiras, Inês | - |
dc.contributor.author | Ferreira, Cláudia | - |
dc.contributor.author | Teixeira, Anabela Claro | - |
dc.contributor.author | Mendes, Vera M. | - |
dc.contributor.author | Novo, Ana Margarida | - |
dc.contributor.author | Machado, Rita | - |
dc.contributor.author | Batista, Sónia | - |
dc.contributor.author | Macário, Maria do Carmo | - |
dc.contributor.author | Grãos, Mário | - |
dc.contributor.author | Sousa, Lívia | - |
dc.contributor.author | Saraiva, Maria João | - |
dc.contributor.author | Pais, Alberto A. C. C. | - |
dc.contributor.author | Duarte, Carlos B. | - |
dc.date.accessioned | 2022-04-05T04:42:43Z | - |
dc.date.available | 2022-04-05T04:42:43Z | - |
dc.date.issued | 2022-02-08 | - |
dc.identifier.issn | 1742-2094 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/99647 | - |
dc.description.abstract | Multiple sclerosis is an inflammatory and degenerative disease of the central nervous system (CNS) characterized by demyelination and concomitant axonal loss. The lack of a single specific test, and the similarity to other inflammatory diseases of the central nervous system, makes it difficult to have a clear diagnosis of multiple sclerosis. Therefore, laboratory tests that allows a clear and definite diagnosis, as well as to predict the different clinical courses of the disease are of utmost importance. Herein, we compared the cerebrospinal fluid (CSF) proteome of patients with multiple sclerosis (in the relapse-remitting phase of the disease) and other diseases of the CNS (inflammatory and non-inflammatory) aiming at identifying reliable biomarkers of multiple sclerosis. | pt |
dc.description.sponsorship | This work was fnanced by the National Multiple Sclerosis Society (USA) (RG-1601-07502), Biogen and by grants from the Portuguese Science and Technology Foundation (FCT), the European Regional Development Fund (ERDF) | pt |
dc.language.iso | eng | pt |
dc.publisher | BMC | pt |
dc.relation | BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias | pt |
dc.relation | UIDB/04539/2020 | pt |
dc.relation | UIDP/04539/2020 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Biomarkers | pt |
dc.subject | Cerebrospinal fluid (CSF) | pt |
dc.subject | Multiple sclerosis | pt |
dc.subject | Transthyretin (TTR) | pt |
dc.title | Posttranslational modifications of proteins are key features in the identification of CSF biomarkers of multiple sclerosis | pt |
dc.type | article | - |
degois.publication.firstPage | 44 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Journal of Neuroinflammation | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1186/s12974-022-02404-2 | pt |
degois.publication.volume | 19 | pt |
dc.date.embargo | 2022-02-08 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | CENTRO-01-0145-FEDER-000008 | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology - CIBB | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | Center for Research in Neuropsychology and Cognitive Behavioral Intervention (CINEICC) | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.parentresearchunit | Faculty of Psychology and Educational Sciences | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0002-2087-4042 | - |
crisitem.author.orcid | 0000-0002-8106-7308 | - |
crisitem.author.orcid | 0000-0002-7020-9606 | - |
crisitem.author.orcid | 0000-0002-4593-673X | - |
crisitem.author.orcid | 0000-0002-6081-6955 | - |
crisitem.author.orcid | 0000-0002-2707-1488 | - |
crisitem.author.orcid | 0000-0002-6725-6460 | - |
crisitem.author.orcid | 0000-0002-1474-0208 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FCTUC Química - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais IIIUC - Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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s12974-022-02404-2.pdf | 5.08 MB | Adobe PDF | View/Open |
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