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Title: Posttranslational modifications of proteins are key features in the identification of CSF biomarkers of multiple sclerosis
Authors: Salazar, Ivan L. 
Lourenço, Ana S. T.
Manadas, Bruno 
Baldeiras, Inês
Ferreira, Cláudia
Teixeira, Anabela Claro
Mendes, Vera M.
Novo, Ana Margarida 
Machado, Rita
Batista, Sónia 
Macário, Maria do Carmo 
Grãos, Mário 
Sousa, Lívia 
Saraiva, Maria João 
Pais, Alberto A. C. C. 
Duarte, Carlos B.
Keywords: Biomarkers; Cerebrospinal fluid (CSF); Multiple sclerosis; Transthyretin (TTR)
Issue Date: 8-Feb-2022
Publisher: BMC
Project: BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias 
Serial title, monograph or event: Journal of Neuroinflammation
Volume: 19
Issue: 1
Abstract: Multiple sclerosis is an inflammatory and degenerative disease of the central nervous system (CNS) characterized by demyelination and concomitant axonal loss. The lack of a single specific test, and the similarity to other inflammatory diseases of the central nervous system, makes it difficult to have a clear diagnosis of multiple sclerosis. Therefore, laboratory tests that allows a clear and definite diagnosis, as well as to predict the different clinical courses of the disease are of utmost importance. Herein, we compared the cerebrospinal fluid (CSF) proteome of patients with multiple sclerosis (in the relapse-remitting phase of the disease) and other diseases of the CNS (inflammatory and non-inflammatory) aiming at identifying reliable biomarkers of multiple sclerosis.
ISSN: 1742-2094
DOI: 10.1186/s12974-022-02404-2
Rights: openAccess
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais

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