Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/92473
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ferreira, Raquel | - |
dc.contributor.author | Napoli, Joseph | - |
dc.contributor.author | Enver, Tariq | - |
dc.contributor.author | Bernardino, Liliana | - |
dc.contributor.author | Ferreira, Lino | - |
dc.date.accessioned | 2021-01-14T12:06:01Z | - |
dc.date.available | 2021-01-14T12:06:01Z | - |
dc.date.issued | 2020-08-26 | - |
dc.identifier.uri | https://hdl.handle.net/10316/92473 | - |
dc.description.abstract | Retinoids regulate a wide spectrum of cellular functions from the embryo throughout adulthood, including cell differentiation, metabolic regulation, and inflammation. These traits make retinoids very attractive molecules for medical purposes. In light of some of the physicochemical limitations of retinoids, the development of drug delivery systems offers several advantages for clinical translation of retinoid-based therapies, including improved solubilization, prolonged circulation, reduced toxicity, sustained release, and improved efficacy. In this Review, we discuss advances in preclinical and clinical tests regarding retinoid formulations, specifically the ones based in natural retinoids, evaluated in the context of regenerative medicine, brain, cancer, skin, and immune diseases. Advantages and limitations of retinoid formulations, as well as prospects to push the field forward, will be presented. | pt |
dc.description.sponsorship | Cerebrovascular Disease Grant and L’Oréal-UNESCO Portugal for Women in Science | pt |
dc.language.iso | eng | pt |
dc.publisher | Nature | pt |
dc.relation | POCI-01-0145-FEDER-016390/CANCELSTEM - Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy (CANCEL_STEM) | pt |
dc.relation | 2IQBIONEURO (reference: 0624_2IQBIONEURO_6_E) | pt |
dc.relation | UID/Multi/00709/2013 | pt |
dc.relation | POCI-01-0145- 619 FEDER-029414 (acronym: LIghtBRARY) | pt |
dc.relation | NEUROATLANTIC (reference: EAPA_791/2018) | pt |
dc.relation | SFRH/BPD/94228/2013 | pt |
dc.relation | IF/00178/2015 | pt |
dc.relation | CENTRO-01-0145-FEDER-000013/ICON - Interdisciplinary Challenges On Neurodegeneration | pt |
dc.relation | EXPL/BIM-MED/0822/2013 (LB) | pt |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/669088/EU/Enhancing Research in Ageing at the University of Coimbra | pt |
dc.relation | SFRH/BPD/102103/2014 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.title | Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine | pt |
dc.type | article | - |
degois.publication.title | Nature Communications | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1038/s41467-020-18042-2 | pt |
degois.publication.volume | 11 | pt |
dc.date.embargo | 2020-08-26 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
crisitem.project.grantno | 0624_2IQBIONEURO_6_E | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0001-8985-9302 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Ferreira et al., Nat Communications.pdf | 2.03 MB | Adobe PDF | View/Open |
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