Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/8087
DC FieldValueLanguage
dc.contributor.authorDelgado, T. C.-
dc.contributor.authorBarosa, C.-
dc.contributor.authorCastro, M. M. C. A.-
dc.contributor.authorGeraldes, C. F. G. C.-
dc.contributor.authorBastos, M.-
dc.contributor.authorBaptista, C.-
dc.contributor.authorFagulha, A.-
dc.contributor.authorBarros, L.-
dc.contributor.authorMota, A.-
dc.contributor.authorCarvalheiro, M.-
dc.contributor.authorJones, J. G.-
dc.contributor.authorMerritt, Matthew-
dc.date.accessioned2009-02-09T11:10:48Z-
dc.date.available2009-02-09T11:10:48Z-
dc.date.issued2008en_US
dc.identifier.citationMagnetic Resonance in Medicine. 60:3 (2008) 517-523en_US
dc.identifier.urihttp://hdl.handle.net/10316/8087-
dc.description.abstractThe contribution of gluconeogenesis to hepatic glucose production (GP) was quantified after 2H2O ingestion by Bayesian analysis of the position 2 and 5 2H-NMR signals (H2 and H5) of monoacetone glucose (MAG) derived from urinary acetaminophen glucuronide. Six controls and 10 kidney transplant (KTx) patients with cyclosporine A (CsA) immunosuppressant therapy were studied. Seven KTx patients were lean and euglycemic (BMI = 24.3 ± 1.0 kg/m2; fasting glucose = 4.7 ± 0.1 mM) while three were obese and hyperglycemic (BMI = 30.5 ± 0.7 kg/m2; fasting glucose = 7.1 ± 0.5 mM). For the 16 spectra analyzed, the mean coefficient of variation for the gluconeogenesis contribution was 10% ± 5%. This uncertainty was associated with a mean signal-to-noise ratio (SNR) of 79:1 and 45:1 for the MAG H2 and H5 signals, respectively. For control subjects, gluconeogenesis contributed 54% ± 7% of GP as determined by the mean and standard deviation (SD) of individual Bayesian analyses. For the lean/normoglycemic KTx subjects, the gluconeogenic contribution to GP was 62% ± 7% (P = 0.06 vs. controls), while hyperglycemic/obese KTx patients had a gluconeogenic contribution of 68% ± 3% (P < 0.005 vs. controls). These data suggest that in KTx patients, an increased gluconeogenic contribution to GP is strongly associated with obesity and hyperglycemia. Magn Reson Med 60:517-523, 2008. © 2008 Wiley-Liss, Inc.en_US
dc.language.isoengeng
dc.rightsopenAccesseng
dc.titleSources of hepatic glucose production by 2H2O ingestion and Bayesian analysis of 2H glucuronide enrichmenten_US
dc.typearticleen_US
dc.identifier.doi10.1002/mrm.21681en_US
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.deptFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.parentdeptUniversidade de Coimbra-
crisitem.author.researchunitCoimbra Chemistry Center-
crisitem.author.orcid0000-0002-0837-8329-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
Files in This Item:
File Description SizeFormat
obra.pdf176.74 kBAdobe PDFView/Open
Show simple item record

SCOPUSTM   
Citations

7
checked on Nov 8, 2019

WEB OF SCIENCETM
Citations

7
checked on Nov 7, 2019

Page view(s) 50

259
checked on Nov 19, 2019

Download(s) 5

2,056
checked on Nov 19, 2019

Google ScholarTM

Check

Altmetric

Dimensions


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.