Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/8070
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Manco, Licínio | - |
dc.contributor.author | Machado, Patrícia | - |
dc.contributor.author | Lopes, Dinora | - |
dc.contributor.author | Nogueira, Fátima | - |
dc.contributor.author | Rosário, Virgílio E. do | - |
dc.contributor.author | Alonso, Pedro L. | - |
dc.contributor.author | Varandas, Luís | - |
dc.contributor.author | Trovoada, Maria de Jesus | - |
dc.contributor.author | Amorim, António | - |
dc.contributor.author | Arez, Ana Paula | - |
dc.date.accessioned | 2009-02-09T11:06:02Z | - |
dc.date.available | 2009-02-09T11:06:02Z | - |
dc.date.issued | 2009 | en_US |
dc.identifier.citation | American Journal of Human Biology. 21:1 (2009) 118-120 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/8070 | - |
dc.description.abstract | Population samples from Angola, Mozambique, and S. Tomé e Príncipe were screened for the TPI gene promoter variants -5ArarrG, -8GrarrA and -24TrarrG. Three haplotypes were identified in the three populations: the haplotype -5A-8G-24T (average frequency 65.3%) and two less common haplotypes -5G-8G-24T (average frequency 24.7%) and -5G-8A-24T (average frequency 10.0%). A population sample from Central Portugal showed the haplotype -5A-8G-24T in 139 chromosomes and one subject heterozygous for haplotype -5G-8A-24G. The exact test of sample differentiation among three groups of malaria-infected individuals classified according to the severity of the disease showed no significant differences. We confirmed TPI gene diversity in sub-Saharan Africa, but we could not detect any association between TPI promoter variation and a malarial protective effect. Larger scale epidemiological studies are thus required to clarify this putative mechanism of natural host defense against this worldwide public health problem | en_US |
dc.language.iso | eng | eng |
dc.publisher | Wiley-Liss | - |
dc.rights | openAccess | eng |
dc.title | Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1002/ajhb.20819 | en_US |
uc.controloAutoridade | Sim | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
crisitem.author.researchunit | CIAS - Research Centre for Anthropology and Health | - |
crisitem.author.orcid | 0000-0002-2636-0288 | - |
Appears in Collections: | I&D CIAS - Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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