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Title: Preparation and physicochemical characterization of omeprazole:methyl-beta-cyclodextrin inclusion complex in solid state
Authors: Figueiras, Ana 
Ribeiro, Laura 
Vieira, M. 
Veiga, Francisco 
Issue Date: 2007
Citation: Journal of Inclusion Phenomena and Macrocyclic Chemistry. 57:1 (2007) 173-177
Abstract: Abstract In this work, we illustrate the usefulness of cyclodextrins, namely, methyl-ß-cyclodextrin (MßCD), an amorphous, methylated derivative of the natural ß-cyclodextrin (ßCD), as a tool to form an inclusion complex with omeprazole (OME), a poorly water soluble drug. Solid binary systems between OME and MßCD were prepared experimentally in a stoichiometry 1:1 by different techniques (physical mixing, kneading, spray-drying and freeze-drying). Afterward these products were characterized by Fourier transformation-infrared spectroscopy (FTIR); X-ray diffractometry (XRD) and scanning electron microscopy (SEM). The results obtained suggest that spray-drying and freeze-drying methods yield a higher degree of amorphous entities suggesting the formation of inclusion complexes between OME and MßCD.
DOI: 10.1007/s10847-006-9200-4
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

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