Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/7910
Title: Regulation of AMPA Receptors by Phosphorylation
Authors: Carvalho, Ana Luísa 
Duarte, Carlos B. 
Carvalho, Arsélio P. 
Issue Date: 2000
Citation: Neurochemical Research. 25:9 (2000) 1245-1255
Abstract: The AMPA receptors for glutamate are oligomeric structures that mediate fast excitatory responses in the central nervous system. Phosphorylation of AMPA receptors is an important mechanism for short-term modulation of their function, and is thought to play an important role in synaptic plasticity in different brain regions. Recent studies have shown that phosphorylation of AMPA receptors by cAMP-dependent protein kinase (PKA) and Ca2+ - and calmodulin-dependent protein kinase II (CaMKII) potentiates their activity, but phosphorylation of the receptor subunits may also affect their interaction with intracellular proteins, and their expression at the plasma membrane. Phosphorylation of AMPA receptor subunits has also been investigated in relation to processes of synaptic plasticity. This review focuses on recent advances in understanding the molecular mechanisms of regulation of AMPA receptors, and their implications in synaptic plasticity.
URI: http://hdl.handle.net/10316/7910
DOI: 10.1023/A:1007644128886
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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