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https://hdl.handle.net/10316/5866
Título: | Characterization of insulin-loaded alginate nanoparticles produced by ionotropic pre-gelation through DSC and FTIR studies | Autor: | Sarmento, Bruno Ferreira, Domingos Veiga, Francisco Ribeiro, António |
Palavras-chave: | Alginate; Chitosan; Insulin; Nanoparticles | Data: | 2006 | Citação: | Carbohydrate Polymers. 66:1 (2006) 1-7 | Resumo: | Insulin-loaded nanoparticles were prepared by ionotropic pre-gelation of alginate with calcium chloride followed by complexation between alginate and chitosan. The influence of the pH and stoichiometry relationship between polyelectrolytes providing individual particles with a nano-scale size was assessed by photon correlation spectroscopy (PCS) and scanning electron microscopy (SEM). Insulin-polyelectrolyte interactions at varying pH and polyelectrolytes stoichiometry were assessed by differential scanning calorimetry (DSC) and Fourier-transform infrared (FTIR) studies. Individual and smaller sizing nanoparticles, around 800 nm, were obtained at pH 4.7 with an alginate:chitosan mass ratio of 6:1. Thermograms of insulin-loaded nanoparticles originated shifts on same unloaded nanoparticle peaks and suggested polyelectrolytes-protein interactions at pH around 4.5-5.0. FTIR spectra of insulin-loaded nanoparticles showed amide absorption bands characteristic of protein spectra and revealed the formation of new chemical entities. | URI: | https://hdl.handle.net/10316/5866 | DOI: | 10.1016/j.carbpol.2006.02.008 | Direitos: | openAccess |
Aparece nas coleções: | FFUC- Artigos em Revistas Internacionais |
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file71d15070522e4521a63d26e06428e79f.pdf | 311.97 kB | Adobe PDF | Ver/Abrir |
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