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dc.contributor.authorSilva, Cláudia L.-
dc.contributor.authorPereira, Jorge C.-
dc.contributor.authorRamalho, Amílcar-
dc.contributor.authorPais, Alberto A. C. C.-
dc.contributor.authorSousa, João J. S.-
dc.identifier.citationJournal of Membrane Science. 320:1-2 (2008) 268-279en_US
dc.description.abstractNovel chitosan based polyelectrolyte complexes (PEC) were developed and optimized in order to obtain films possessing the optimal functional properties (flexibility, resistance, water vapour transmission rate and bioadhesion) to be applied on skin. The development was based on the combination of chitosan and two polyacrylic acid (PAA) polymers with different crosslinkers and crosslinking densities. The interaction between the polymers was maximized controlling the pH, and by forming the films at a pH value close to the pKa of the respective components as identified by potentiometric and turbidimetric titrations. The action of glycerol, PEG200, Hydrovance and trehalose upon the functional properties of the films was also evaluated. Glycerol was found to improve the film properties in terms of flexibility, resistance and water vapour transmission rate (WVTR) with a maximum effect at 30%. The application of a pressure sensitive adhesive (PSA) significantly improved bioadhesion with a negligible influence in the resistance and flexibility of the films.en_US
dc.subjectPolyelectrolyte complexesen_US
dc.subjectSkin drug deliveryen_US
dc.titleFilms based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterizationen_US
item.fulltextCom Texto completo-
item.languageiso639-1en- de Ciências e Tecnologia, Universidade de Coimbra- de Ciências e Tecnologia, Universidade de Coimbra- de Ciências e Tecnologia, Universidade de Coimbra- de Farmácia, Universidade de Coimbra- de Coimbra- de Coimbra- de Coimbra- Chemistry Center- for Mechanical Engineering- Chemistry Center- Chemistry Center-
Appears in Collections:FFUC- Artigos em Revistas Internacionais
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