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Title: Angiotensin II mediates catecholamine and neuropeptide Y secretion in human adrenal chromaffin cells through the AT1 receptor
Authors: Cavadas, Cláudia 
Grand, Daniela 
Mosimann, François 
Cotrim, Maria Dulce 
Ribeiro, Carlos Alberto Fontes 
Brunner, Hans R. 
Grouzmann, Eric 
Keywords: Human adrenal chromaffin cells; Catecholamines; Neuropeptide Y; Angiotensin II; AT1 receptor; AT2 receptor
Issue Date: 2003
Citation: Regulatory Peptides. 111:1-3 (2003) 61-65
Abstract: The aim of the present work was to study the effect of angiotensin II (Ang II) on catecholamines and neuropeptide Y (NPY) release in primary cultures of human adrenal chromaffin cells. Ang II stimulates norepinephrine (NE), epinephrine (EP) and NPY release from perifused chromaffin cells by 3-, 2- and 12-fold, respectively. The NPY release is more sustained than that of catecholamines. We found that the receptor-AT2 agonist, T2-(Ang II 4-8)2 has no effect on NE, EP and NPY release from chromaffin cells. We further showed that Ang II increases intracellular Ca2+ concentration ([Ca2+]i). The selective AT1-receptor antagonist Candesartan blocked [Ca2+]i increase by Ang II, while T2-(Ang II 4-8)2 was ineffective. These findings demonstrate that AT1 stimulation induces catecholamine secretion from human adrenal chromaffin cells probably by raising cytosolic calcium.
DOI: 10.1016/s0167-0115(02)00253-7
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

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