Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/5782
Title: Angiotensin II mediates catecholamine and neuropeptide Y secretion in human adrenal chromaffin cells through the AT1 receptor
Authors: Cavadas, Cláudia 
Grand, Daniela 
Mosimann, François 
Cotrim, Maria Dulce 
Ribeiro, Carlos Alberto Fontes 
Brunner, Hans R. 
Grouzmann, Eric 
Keywords: Human adrenal chromaffin cells; Catecholamines; Neuropeptide Y; Angiotensin II; AT1 receptor; AT2 receptor
Issue Date: 2003
Citation: Regulatory Peptides. 111:1-3 (2003) 61-65
Abstract: The aim of the present work was to study the effect of angiotensin II (Ang II) on catecholamines and neuropeptide Y (NPY) release in primary cultures of human adrenal chromaffin cells. Ang II stimulates norepinephrine (NE), epinephrine (EP) and NPY release from perifused chromaffin cells by 3-, 2- and 12-fold, respectively. The NPY release is more sustained than that of catecholamines. We found that the receptor-AT2 agonist, T2-(Ang II 4-8)2 has no effect on NE, EP and NPY release from chromaffin cells. We further showed that Ang II increases intracellular Ca2+ concentration ([Ca2+]i). The selective AT1-receptor antagonist Candesartan blocked [Ca2+]i increase by Ang II, while T2-(Ang II 4-8)2 was ineffective. These findings demonstrate that AT1 stimulation induces catecholamine secretion from human adrenal chromaffin cells probably by raising cytosolic calcium.
URI: http://hdl.handle.net/10316/5782
DOI: 10.1016/s0167-0115(02)00253-7
10.1016/S0167-0115(02)00253-7
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
file412581d91e0345a8ad62e787ebed6ac6.pdf118.43 kBAdobe PDFView/Open
Show full item record

WEB OF SCIENCETM
Citations 5

24
checked on Nov 15, 2022

Page view(s) 50

471
checked on Dec 5, 2022

Download(s) 20

886
checked on Dec 5, 2022

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.