Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/5759
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dc.contributor.authorRibeiro, Laura-
dc.contributor.authorCarvalho, Rui A.-
dc.contributor.authorFerreira, Domingos C.-
dc.contributor.authorVeiga, Francisco J. B.-
dc.date.accessioned2008-09-26T17:41:15Z-
dc.date.available2008-09-26T17:41:15Z-
dc.date.issued2005en_US
dc.identifier.citationEuropean Journal of Pharmaceutical Sciences. 24:1 (2005) 1-13en_US
dc.identifier.urihttp://hdl.handle.net/10316/5759-
dc.description.abstractThis work deals with multicomponent complex formation of vinpocetine (VP) with [beta]-cyclodextrin ([beta]CD), sulfobutyl ether [beta]-cyclodextrin (SBE[beta]CD) and tartaric acid (TA), in the presence or absence of water-soluble polymers, in aqueous solution. Complexation was monitored by phase-solubility and proton nuclear magnetic resonance (1H NMR) studies. TA demonstrated a synergistic effect on VP solubility, and in the complexation efficiency of [beta]CD and SBE[beta]CD. Additionally, water-soluble polymers increased even more the complexation efficiency of the CDs that was reflected by a 2.1-2.5 increase on KC values for VP-CD-TA-polymer multicomponent complexes. SBE[beta]CD was more effective in VP solubilization, as KC values of VP-SBE[beta]CD-TA multicomponent complexes were notably higher than in corresponding [beta]CD complexes. The large chemical shift displacements from protons located in the interior of the hydrophobic CD cavities (i.e., H-3 and H-5) coupled with significant chemical shift displacements of VP aromatic protons suggested that this moiety was included in the cavity of both [beta]CD and SBE[beta]CD. Two-dimensional rotating frame nuclear Overhauser effect spectroscopy (ROESY) experiments were carried out in order to obtain information about the multicomponent complex geometry in solution. Inspection of ROESY spectra allowed the establishment of spatial proximities between all aromatic protons of VP and the internal protons of the CDs, confirming that the aromatic moiety of VP is included in CD cavities being deeply inserted in SBE[beta]CD multicomponent complexes, since additional interactions with the sulfobutyl side chains were evidenced.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6T25-4DT2KX7-1/1/a543ba03bff16fe4ef579956893c94b5en_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectVinpocetineen_US
dc.subjectCyclodextrinsen_US
dc.subjectWater-soluble polymersen_US
dc.subjectPhase-solubility studiesen_US
dc.subjectMulticomponent complexesen_US
dc.titleMulticomponent complex formation between vinpocetine, cyclodextrins, tartaric acid and water-soluble polymers monitored by NMR and solubility studiesen_US
dc.typearticleen_US
item.fulltextCom Texto completo-
item.languageiso639-1en-
item.grantfulltextopen-
crisitem.author.deptFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.parentdeptUniversidade de Coimbra-
crisitem.author.researchunitCNC.IBILI-
crisitem.author.orcid0000-0003-1820-0353-
Appears in Collections:FFUC- Artigos em Revistas Internacionais
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