Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/5463
Título: | Decreased susceptibility to lipid peroxidation of Goto-Kakizaki rats: Relationship to mitochondrial antioxidant capacity | Autor: | Ferreira, F. M. L. Palmeira, C. M. Matos, M. J. Seiça, R. Santos, M. S. |
Palavras-chave: | Goto-Kakizaki rats; type 2 diabetes mellitus; mitochondria; respiratory index; lipid peroxidation; antioxidant enzymes; [alpha]-tocopherol | Data: | 1999 | Citação: | Life Sciences. 65:10 (1999) 1013-1025 | Resumo: | The respiratory function and the antioxidant capacity of liver mitochondrial preparations isolated from Goto-Kakizaki non-insulin dependent diabetic rats and from Wistar control rats, with the age of 6 months, were compared. It was found that Goto-Kakizaki mitochondrial preparations presented a higher coupling between oxidative and phosphorylative systems, compared to non-diabetic preparations. Goto-Kakizaki mitochondria presented a lower susceptibility to lipid peroxidation induced by ADP/Fe2+, as evaluated by the formation of thiobarbituric acid substances. The decreased susceptibility to peroxidation in diabetic rats was correlated with an increase in mitochondrial vitamin E ([alpha]-tocopherol) content and GSH/GSSG ratio. Moreover, the glutathione reductase activity was significantly increased, whereas the glutathione peroxidase was decreased. Superoxide dismutase activity was unchanged in diabetic rats. Fatty acid analyses showed that the content in polyunsaturated fatty acids of Goto-Kakizaki mitochondrial membranes was significantly higher compared to controls. These results indicate that the lower susceptibility to lipid peroxidation of mitochondria from diabetic rats was related to their antioxidant defense systems, and may correspond to an adaptative response of the cells against oxidative stress in the early phase of diabetes. | URI: | https://hdl.handle.net/10316/5463 | DOI: | 10.1016/S0024-3205(99)00332-X | Direitos: | openAccess |
Aparece nas coleções: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
filead67ddb4b1984c3594b276a0e6ad2e64.pdf | 1.03 MB | Adobe PDF | Ver/Abrir |
Citações SCOPUSTM
38
Visto em 22/abr/2024
Citações WEB OF SCIENCETM
38
Visto em 2/abr/2024
Visualizações de página
286
Visto em 23/abr/2024
Downloads 20
1.142
Visto em 23/abr/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.