Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/5447
Título: | Induction of the Mitochondrial Permeability Transition in Vitro by Short-Chain Carboxylic Acids | Autor: | Palmeira, C. M. Rana, M. I. Frederick, C. B. Wallace, K. B. |
Palavras-chave: | liver mitochondria; permeability transition; carboxylic acids; cyclosporine A | Data: | 2000 | Citação: | Biochemical and Biophysical Research Communications. 272:2 (2000) 431-435 | Resumo: | We recently reported that acrylic acid (AA) induces the MPT in vitro, which we suggested might be a critical event in the acute inflammatory and hyperplastic response of the olfactory epithelium. The purpose of the present investigation was to determine if induction of the MPT is a general response to short-chain carboxylic acids or if there are critical physical chemical parameters for this response. Freshly isolated rat liver mitochondria were incubated in the presence of varying concentrations of selected carboxylic acids. All of the acids that we tested caused a concentration-dependent induction of the MPT, which was blocked by cyclosporine A. Although the C4 carboxylic acids were slightly more potent than the C5 acids, there was no correlation with the degree of saturation, the octanol/water coefficient (log P), or the dissociation constant (pKa) of the acids that we tested. We conclude that induction of the MPT in vitro is a general response to short-chain carboxylic acids having a pKa of 4 to 5. | URI: | https://hdl.handle.net/10316/5447 | DOI: | 10.1006/bbrc.2000.2797 | Direitos: | openAccess |
Aparece nas coleções: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
file551759df141443b3824c8498c8d7e7ed.pdf | 70.88 kB | Adobe PDF | Ver/Abrir |
Citações SCOPUSTM
9
Visto em 17/nov/2022
Citações WEB OF SCIENCETM
50
8
Visto em 2/mai/2023
Visualizações de página 50
518
Visto em 17/abr/2024
Downloads 50
534
Visto em 17/abr/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.