Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/5278
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dc.contributor.authorBrett, A. M. Oliveira-
dc.contributor.authorMacedo, T. R. A.-
dc.contributor.authorRaimundo, D.-
dc.contributor.authorMarques, M. H.-
dc.contributor.authorSerrano, S. H. P.-
dc.date.accessioned2008-09-01T15:06:59Z-
dc.date.available2008-09-01T15:06:59Z-
dc.date.issued1998en_US
dc.identifier.citationBiosensors and Bioelectronics. 13:7-8 (1998) 861-867en_US
dc.identifier.urihttp://hdl.handle.net/10316/5278-
dc.description.abstractThe surface of an electrochemical glassy carbon electrode was modified with a layer of double-stranded DNA (dsDNA) or with double-stranded DNA conditioned in single-stranded DNA (ssDNA) and was used to investigate mitoxantrone-DNA interactions. Differential pulse and square wave voltammetry were applied to develop an electroanalytical procedure for the determination of mitoxantrone and evaluate its interaction with dsDNA or ssDNA immobilized on the electrode surface. The results demonstrate that MTX interaction with DNA is not specific to either guanine or adenine bases. The kinetics of the mitoxantrone-DNA interaction is slow and damage to DNA was followed with time.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6TFC-3V7468X-M/1/0e51372fcf9dc0c815a23de2d3e08795en_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectBioelectrochemistryen_US
dc.subjectDNA interactionen_US
dc.subjectMitoxantroneen_US
dc.subjectDNA-biosensoren_US
dc.subjectVoltammetryen_US
dc.titleVoltammetric behaviour of mitoxantrone at a DNA-biosensoren_US
dc.typearticleen_US
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
crisitem.author.deptFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.parentdeptUniversidade de Coimbra-
crisitem.author.researchunitCentre for Mechanical Engineering-
crisitem.author.orcid0000-0002-6244-0891-
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais
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