Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/5269
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dc.contributor.authorBrett, A. M. Oliveira-
dc.contributor.authorMacedo, T. R. A.-
dc.contributor.authorRaimundo, D.-
dc.contributor.authorMarques, M. H.-
dc.contributor.authorSerrano, S. H. P.-
dc.date.accessioned2008-09-01T15:06:50Z-
dc.date.available2008-09-01T15:06:50Z-
dc.date.issued1999en_US
dc.identifier.citationAnalytica Chimica Acta. 385:1-3 (1999) 401-408en_US
dc.identifier.urihttp://hdl.handle.net/10316/5269-
dc.description.abstractMitoxantrone is an anthracycline used as an antitumour antibiotic for leukaemia and breast cancer treatment, due to its interaction with DNA. However, the molecular mechanism of the antitumour action is not completely understood. Using a glassy carbon electrode the electrochemical oxidation of mitoxantrone was shown to be a complex, pH-dependent, irreversible electrode process involving several metabolites. Comparison of the electrochemical oxidation behaviour of mitoxantrone, ametantrone and aminantrone enabled a deeper understanding of the mechanism and showed the relevance of electrochemical data for the understanding of the cytotoxicity of mitoxantrone. Since mitoxantrone and its oxidation products adsorb strongly on the electrode surface, causing severe problems of electrode fouling, reproducible electroanalytical determinations could only be done at very low concentrations and in an aqueous buffer supporting electrolyte containing 30% ethanol. The detection limit obtained was 10-7 M.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6TF4-3W3N6Y2-1J/1/5ffa47da56de732d1903bdf9a6c163c9en_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectBioelectrochemistryen_US
dc.subjectMitoxantrone oxidationen_US
dc.subjectVoltammetryen_US
dc.titleElectrochemical oxidation of mitoxantrone at a glassy carbon electrodeen_US
dc.typearticleen_US
item.fulltextCom Texto completo-
item.languageiso639-1en-
item.grantfulltextopen-
crisitem.author.deptFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.parentdeptUniversidade de Coimbra-
crisitem.author.researchunitCentre for Mechanical Engineering-
crisitem.author.orcid0000-0002-6244-0891-
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais
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