Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/5259
Title: | Electrochemical studies and square wave adsorptive stripping voltammetry of the antidepressant fluoxetine | Authors: | Silva, A. M. S. Roque da Lima, J. C. Teles, M. T. Oliva Brett, A. M. Oliveira |
Keywords: | Fluoxetine; Electrochemistry; Antidepressant; Pharmaceutical formulations | Issue Date: | 1999 | Citation: | Talanta. 49:3 (1999) 611-617 | Abstract: | The electrochemical reduction of the antidepressant drug fluoxetine was investigated by cyclic, linear sweep, differential pulse and square wave voltammetry using a hanging mercury drop electrode in alkaline buffer solution in water and in a water/acetonitrile mixed solvent. Cyclic voltammograms in aqueous solution showed very strong adsorption of fluoxetine on the electrode with formation of a compact film. The effect of addition of different percentages of acetonitrile on the voltammetric response was evaluated. It is shown that acetonitrile protects the electrode surface, thus preventing the adsorption of fluoxetine as a compact film, although reduction occurs at more negative potentials. Adsorption was used to accumulate the drug onto the electrode surface. The adsorbed species were measured voltammetrically by reduction at -1.3 V in an aqueous 0.05 M Ringer buffer, pH 12, 20% acetonitrile v/v. Linear calibration graphs were obtained in the range 0.52-5.2 M. The quantification of fluoxetine in pharmacological formulations existing in the market was performed using adsorptive square wave cathodic stripping voltammetry. and compared with data from UV spectrophotometry. The method is simple and not time-consuming. A comparative high performance liquid chromatography assay with UV detection was performed. Recovery data for both methods are reported. | URI: | https://hdl.handle.net/10316/5259 | DOI: | 10.1016/S0039-9140(99)00050-8 | Rights: | openAccess |
Appears in Collections: | FCTUC Química - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
file325810da36704c11a9f61f10078cbc06.pdf | 122.9 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
43
checked on Apr 22, 2024
WEB OF SCIENCETM
Citations
45
checked on Apr 2, 2024
Page view(s)
306
checked on Apr 16, 2024
Download(s)
200
checked on Apr 16, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.