Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/5137
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dc.contributor.authorPinho e Melo, Teresa M. V. D.-
dc.contributor.authorSantos, Catarina I. A.-
dc.contributor.authorRocha Gonsalves, António M. dA.-
dc.contributor.authorPaixão, José A.-
dc.contributor.authorBeja, Ana M.-
dc.date.accessioned2008-09-01T15:04:35Z-
dc.date.available2008-09-01T15:04:35Z-
dc.date.issued2004en_US
dc.identifier.citationTetrahedron. 60:18 (2004) 3949-3955en_US
dc.identifier.urihttp://hdl.handle.net/10316/5137-
dc.description.abstractThe thermolysis of (3R,9bS)-5-oxo-2,3,5,9b-tetrahydrothiazolo[2,3-a]isoindole-3-carboxylic acids in Ac2O led to novel 3-methylene-2,5-dioxo-3H,9bH-oxazolo[2,3-a]isoindoles and chiral (9bS)-5-oxo-2,3,5,9b-tetrahydrothiazolo[2,3-a]isoindoles were obtained on FVP. Starting from -cysteine methyl ester (3R,10bR)-5-oxo-2,3-dihydro-10bH-[1.3]thiazolo[3,2-c][1,3]benzoxazines were obtained as single stereoisomers. The thermolysis of (3R,10bR)-5-oxo-2,3-dihydro-10bH-[1.3]thiazolo[3,2-c][1,3]benzoxazine-3-carboxylic acid in Ac2O gave 5-acetyl-2-phenyl-2,3-dihydrothiazole. The structures of methyl (3R,9bS)-5-oxo-2,3,5,9b-tetrahydrothiazolo[2,3-a]isoindole-3-carboxylate 1a and methyl (2R,4R)-N-chlorocarbonyl-2-(2-hydroxyphenyl)thiazolidine-4-carboxylate 9 were determined by X-ray crystallography.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6THR-4C40YF0-8/1/7705fb68c2f9e77d90918a00a3d71e74en_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectDiastereoselectivityen_US
dc.subjectThiazolo[2,3-a]isoindolesen_US
dc.subject3-Methylene-2,5-oxazolo[2,3-a]isoindolesen_US
dc.subject[1.3]Thiazolo[3,2-c][1,3]benzoxazinesen_US
dc.titleSynthesis of tricyclic isoindoles and thiazolo[3,2-c][1,3]benzoxazinesen_US
dc.typearticleen_US
uc.controloAutoridadeSim-
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
crisitem.author.deptFaculdade de Farmácia, Universidade de Coimbra-
crisitem.author.deptFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.deptFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.parentdeptUniversidade de Coimbra-
crisitem.author.parentdeptUniversidade de Coimbra-
crisitem.author.researchunitCoimbra Chemistry Center-
crisitem.author.researchunitCoimbra Chemistry Center-
crisitem.author.researchunitCenter for Physics, University of Coimbra-
crisitem.author.parentresearchunitFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.parentresearchunitFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.orcid0000-0003-3256-4954-
crisitem.author.orcid0000-0001-9987-7301-
crisitem.author.orcid0000-0003-4634-7395-
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais
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