Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/4799
DC FieldValueLanguage
dc.contributor.authorFerreira, Fernanda M.-
dc.contributor.authorSeiça, Raquel-
dc.contributor.authorOliveira, Paulo J.-
dc.contributor.authorCoxito, Pedro M.-
dc.contributor.authorMoreno, António J.-
dc.contributor.authorPalmeira, Carlos M.-
dc.contributor.authorSantos, Maria S.-
dc.date.accessioned2008-09-01T14:14:40Z-
dc.date.available2008-09-01T14:14:40Z-
dc.date.issued2003en_US
dc.identifier.citationBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1639:2 (2003) 113-120en_US
dc.identifier.urihttps://hdl.handle.net/10316/4799-
dc.description.abstractSeveral studies have been carried out to evaluate the alterations in mitochondrial functions of diabetic rats. However, results are sometimes controversial, since experimental conditions diverge, including age and strain of used animals. The purpose of this study was to evaluate the metabolic modifications in liver mitochondria, both in the presence of severe (STZ-treated rats) and mild hyperglycaemia [Goto-Kakizaki (GK) rats], when compared with control animals of similar age. Moreover, metabolic alterations were evaluated also at initial and advanced stages of the disease.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6T1Y-49FPHJH-1/1/3b97418b61eef86377c47c0fc15ca3d1en_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectDiabetes mellitusen_US
dc.subjectType 1 diabetesen_US
dc.subjectType 2 diabetesen_US
dc.subjectGoto-Kakizaki (GK) raten_US
dc.subjectStreptozotocin-induced diabetic (STZ) raten_US
dc.subjectMitochondrial permeability transition (MPT)en_US
dc.titleDiabetes induces metabolic adaptations in rat liver mitochondria: role of coenzyme Q and cardiolipin contentsen_US
dc.typearticleen_US
dc.identifier.doi10.1016/j.bbadis.2003.08.001-
uc.controloAutoridadeSim-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypearticle-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.languageiso639-1en-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitMARE - Marine and Environmental Sciences Centre-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0002-8378-0895-
crisitem.author.orcid0000-0002-5201-9948-
crisitem.author.orcid0000-0003-3575-7604-
crisitem.author.orcid0000-0002-2639-7697-
crisitem.author.orcid0000-0002-6881-9392-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
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