Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/4791
Title: Family association study between DRD2 and DRD3 gene polymorphisms and schizophrenia in a Portuguese population
Authors: Ambrósio, Alda M. 
Kennedy, James L. 
Macciardi, Fabio 
Macedo, António 
Valente, José 
Dourado, Ana 
Oliveira, Catarina R. 
Pato, Carlos 
Keywords: Schizophrenia; Association study; Candidate genes; Linkage disequilibrium; Haplotypes
Issue Date: 2004
Citation: Psychiatry Research. 125:3 (2004) 185-191
Abstract: Schizophrenia is a highly heritable condition, as demonstrated in family, twin and adoption studies. Candidate genes from the dopaminergic system have long been hypothesized to be involved in the etiology of this disorder. In the present study, we investigated the genetic association between polymorphisms in the D2 and D3 dopamine receptor (DRD2, DRD3) genes and schizophrenia. We examined 90 trios from Portugal, and negative results were obtained from association studies with both Haplotype Relative Risk (HRR) and Transmission Disequilibrium Test (TDT), as well as TRANSMIT. Therefore, we conclude that neither the DRD2 nor the DRD3 gene polymorphisms investigated are associated with schizophrenia in our sample.
URI: http://hdl.handle.net/10316/4791
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

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