Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/45140
DC Field | Value | Language |
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dc.contributor.author | Milhazes, Nuno | - |
dc.contributor.author | Calheiros, Rita | - |
dc.contributor.author | Marques, M. Paula M. | - |
dc.contributor.author | Garrido, Jorge | - |
dc.contributor.author | Cordeiro, M. Natália D. S. | - |
dc.contributor.author | Rodrigues, Cátia | - |
dc.contributor.author | Quinteira, Sandra | - |
dc.contributor.author | Novais, Carla | - |
dc.contributor.author | Peixe, Luísa | - |
dc.contributor.author | Borges, Fernanda | - |
dc.date.accessioned | 2017-12-15T18:41:01Z | - |
dc.date.available | 2017-12-15T18:41:01Z | - |
dc.date.issued | 2006 | - |
dc.identifier.uri | https://hdl.handle.net/10316/45140 | - |
dc.description.abstract | A multidisciplinary project was developed, combining the synthesis of a series of beta-nitrostyrene derivatives and the determination of their physicochemical parameters (redox potentials, partition coefficients), to the evaluation of the corresponding antibacterial activity. A complete conformational analysis was also performed, in order to get relevant structural information. Subsequently, a structure-property-activity (SPAR) approach was applied, through linear regression analysis, aiming at obtaining a putative correlation between the physicochemical parameters of the compounds investigated and their antibacterial activity (both against standard strains and clinical isolates). The beta-nitrostyrene compounds displayed a lower activity towards all the tested bacteria relative to the beta-methyl-beta-nitrostyrene analogues. This was observed particularly for the 3-hydroxy-4-methoxy-beta-methyl-beta-nitrostyrene (IVb) against the Gram-positive bacteria (Staphylococcus aureus, Enterococcus faecalis and Enterococcus faecium). The SPAR results revealed the existence of a clear correlation between the redox potentials and the antibacterial activity of the series of beta-nitrostyrene derivatives under study. | por |
dc.language.iso | eng | por |
dc.rights | openAccess | por |
dc.subject | Anti-Bacterial Agents | por |
dc.subject | Electrochemistry | por |
dc.subject | Gram-Positive Bacteria | por |
dc.subject | Microbial Sensitivity Tests | por |
dc.subject | Models, Molecular | por |
dc.subject | Molecular Structure | por |
dc.subject | Oxidation-Reduction | por |
dc.subject | Structure-Activity Relationship | por |
dc.subject | Styrenes | por |
dc.title | β-Nitrostyrene derivatives as potential antibacterial agents: A structure–property–activity relationship study | por |
dc.type | article | - |
degois.publication.firstPage | 4078 | por |
degois.publication.lastPage | 4088 | por |
degois.publication.issue | 12 | por |
degois.publication.title | Bioorganic & Medicinal Chemistry | por |
dc.peerreviewed | yes | por |
dc.identifier.doi | 10.1016/j.bmc.2006.02.006 | - |
dc.identifier.doi | 10.1016/j.bmc.2006.02.006 | por |
degois.publication.volume | 14 | por |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
crisitem.author.researchunit | QFM-UC – Molecular Physical-Chemistry R&D Unit | - |
crisitem.author.orcid | 0000-0002-5171-0454 | - |
crisitem.author.orcid | 0000-0002-8391-0055 | - |
crisitem.author.orcid | 0000-0001-8981-231X | - |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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BMC_06_14.pdf | 281.52 kB | Adobe PDF | View/Open |
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