Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/45125
Title: Spectroscopic and electrochemical studies of cocaine–opioid interactions
Authors: Garrido, Jorge M. P. J. 
Marques, M. Paula M. 
Silva, Artur M. S. 
Macedo, Tice R. A. 
Oliveira-Brett, Ana M. 
Borges, Fernanda 
Keywords: Analgesics, Opioid; Binding Sites; Cocaine; Drug Interactions; Electrochemistry; Morphine; Quantum Theory; Solutions; Spectrum Analysis
Issue Date: 2007
Abstract: The drugs of abuse cocaine (C), heroin (H), and morphine (M) have been studied to enable understanding of the occurrence of cocaine-opioid interactions at a molecular level. Electrochemical, Raman, and NMR studies of the free drugs and their mixtures were used to study drug-drug interactions. The results were analyzed using data obtained from quantum-mechanical calculations. For the cocaine-morphine mixture (C-MH), formation of a binary complex was detected; this involved the 3-phenolic group and the heterocyclic oxygen of morphine and the carbonyl oxygen and the methyl protons of cocaine's methyl ester group. NMR studies conducted simultaneously also revealed C-MH binding geometry consistent with theoretical predictions and with electrochemical and vibrational spectroscopy results. These results provide evidence for the occurrence of a cocaine-morphine interaction, both in the solid state and in solution, particularly for the hydrochloride form. A slight interaction, in solution, was also detected by NMR for the cocaine-heroin mixture.
URI: http://hdl.handle.net/10316/45125
Other Identifiers: 10.1007/s00216-007-1375-z
DOI: 10.1007/s00216-007-1375-z
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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