Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/45121
Title: Antioxidant Versus Cytotoxic Properties of Hydroxycinnamic Acid Derivatives – A New Paradigm in Phenolic Research
Authors: Esteves, Mário 
Siquet, Christophe 
Gaspar, Alexandra 
Rio, Vitor 
Sousa, Joana B. 
Reis, Salette 
Marques, Maria P. M. 
Borges, Fernanda 
Keywords: Antineoplastic Agents; Coumaric Acids; Female; Free Radical Scavengers; Free Radicals; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; Liposomes; Oxidative Stress; Structure-Activity Relationship; Uterine Cervical Neoplasms
Issue Date: 2008
Abstract: Trihydroxycinnamic derivatives were synthesized and evaluated for their antioxidant and cytotoxic activities. The ester derivatives exhibited a higher radical-scavenging activity, when liposomes were used as target systems, a fact which may be related to their lipophilicity and conformational preferences. These compounds were found to display significant growth inhibition and cytotoxic effects towards a human cervix adenocarcinoma cell line (HeLa). The partition coefficients presently obtained for the trihydroxycinnamic derivatives correlate well both with their structural characteristics and with their antioxidant/cytotoxic activities. A positive structure-activity-property relationship between cytotoxic and antioxidant activities, which is intrinsically related with physico-chemical and conformational properties, is anticipated, as a noteworthy study that must be done for phenolic systems. As damage events are frequently correlated with oxidative stress, the prevalence of both properties in a single compound could be beneficial in terms of rationale preventive or therapeutic purposes.
URI: http://hdl.handle.net/10316/45121
Other Identifiers: 10.1002/ardp.200700168
DOI: 10.1002/ardp.200700168
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat 
Arch_Pharm_08_341.pdf1.09 MBAdobe PDFView/Open
Show full item record

SCOPUSTM   
Citations

34
checked on Apr 12, 2019

WEB OF SCIENCETM
Citations

31
checked on May 11, 2018

Page view(s)

84
checked on Jun 11, 2019

Download(s)

34
checked on Jun 11, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.