Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/45097
DC Field | Value | Language |
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dc.contributor.author | Fiuza, Sónia M. | - |
dc.contributor.author | Holy, Jon | - |
dc.contributor.author | Carvalho, Luís A. E. Batista de | - |
dc.contributor.author | Marques, Maria P. M. | - |
dc.date.accessioned | 2017-12-15T17:47:29Z | - |
dc.date.available | 2017-12-15T17:47:29Z | - |
dc.date.issued | 2011 | - |
dc.identifier.uri | https://hdl.handle.net/10316/45097 | - |
dc.description.abstract | A dinuclear palladium-based complex (Pd(2) -Spm) was synthesized and compared with cisplatin (cDDP) on two different human breast cancer cell lines (MCF-7 and MDA-MB-231) as well as toward an untransformed cell line (BJ fibroblasts). The results obtained show that Pd(2) -Spm is more effective against the estrogen receptors [ER(-)] cell line MDA-MB-231, while cDDP displayed better results for the ER(+) MCF-7 cell line. It was shown that, like cDDP, Pd(2) -Spm triggers phosphorylation of H2AX, indicating that this compound damages DNA. Apart from DNA, Pd(2) -Spm also targets the cytoskeleton having a greater impact on cell morphology than cDDP. Pd(2) -Spm and cDDP have opposite antiproliferative activities in the presence of the PI3K inhibitor wortmannin. Furthermore, Pd(2) -Spm at an optimized concentration displays a rapid antiproliferative effect as opposed to cDDP, which seems to have a slower kinetics. The results point to a distinct mechanism of action for each of these complexes, which may explain their synergistic action when coadministrated. | por |
dc.language.iso | eng | por |
dc.rights | openAccess | por |
dc.subject | Androstadienes | por |
dc.subject | Antineoplastic Agents | por |
dc.subject | Breast Neoplasms | por |
dc.subject | Cell Line, Tumor | por |
dc.subject | Cell Proliferation | por |
dc.subject | Cytoskeleton | por |
dc.subject | DNA Damage | por |
dc.subject | Female | por |
dc.subject | Humans | por |
dc.subject | Organometallic Compounds | por |
dc.subject | Palladium | por |
dc.subject | Protein Kinase Inhibitors | por |
dc.subject | Spermine | por |
dc.title | Biologic Activity of a Dinuclear Pd(II)-Spermine Complex Toward Human Breast Cancer | por |
dc.type | article | - |
degois.publication.firstPage | 477 | por |
degois.publication.lastPage | 488 | por |
degois.publication.issue | 6 | por |
degois.publication.title | Chemical Biology & Drug Design | por |
dc.peerreviewed | yes | por |
dc.identifier.doi | 10.1111/j.1747-0285.2011.01081.x | - |
dc.identifier.doi | 10.1111/j.1747-0285.2011.01081.x | por |
degois.publication.volume | 77 | por |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
crisitem.author.researchunit | QFM-UC – Molecular Physical-Chemistry R&D Unit | - |
crisitem.author.researchunit | QFM-UC – Molecular Physical-Chemistry R&D Unit | - |
crisitem.author.orcid | 0000-0002-8059-8537 | - |
crisitem.author.orcid | 0000-0002-8391-0055 | - |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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CBDD_11_77.pdf | 449.94 kB | Adobe PDF | View/Open |
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