The effect of reversible binding sites on drug release from drug eluting stents

Abstract

A coupled non-Fickian model of a cardiovascular drug delivery system using a biodegradable drug eluting stent is proposed. The reversible reaction between the drug and the arterial tissue binding sites are taken into account. The proposed model accounts for the different nature of the therapeutic compounds used. The numerical results are obtained using an IMEX finite element method in the variational form.