Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/3798
Title: Synthesis and characterization of new injectable and degradable dextran-based hydrogels
Authors: Maia, João 
Ferreira, Lino 
Carvalho, Rui 
Ramos, Manuel A. 
Gil, Maria H. 
Keywords: Hydrogels; Degradation; Pore size
Issue Date: 2005
Citation: Polymer. 46:23 (2005) 9604-9614
Abstract: Injectable and degradable hydrogels are very interesting networks for drug delivery and cell transplantation applications since they can be administered in the human body in a minimally invasive way. In most cases, the crosslinking reaction occurs by photopolymerisation or free radical polymerisation; however, the use of chemical initiators may promote cell death. In the current work, injectable and degradable dextran-based hydrogels were prepared without the use of initiators. Dextran, a natural glucose-containing polysaccharide, was oxidized with sodium periodate (dexOx) and the derivatives characterized by NMR and FTIR spectroscopy's as well as by colorimetric techniques. The oxidized derivatives were crosslinked with adipic acid dihydrazide (AAD), forming a gel within 2-4 min. The obtained hydrogels were characterized by their mechanical properties, swelling and degradation behavior under physiologic conditions. In addition, the hydrogel interior morphology as well as porous structure was evaluated by scanning electron microscopy (SEM) and mercury intrusion porosimetry (MIP). MIP analysis showed that dexOx hydrogels crosslinked with 10% of AAD were macroporous with pore sizes ranging from 0.32 to 0.08 [mu]m. As expected, the average pore size increased during hydrogel degradation as confirmed by SEM and MIP studies.
URI: http://hdl.handle.net/10316/3798
Rights: openAccess
Appears in Collections:FCTUC Eng.Química - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
file66b3c4a2f8834879953d9cb41316fd10.pdf440.53 kBAdobe PDFView/Open
Show full item record

Page view(s)

189
checked on Oct 16, 2019

Download(s) 50

184
checked on Oct 16, 2019

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.