Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/27752
DC FieldValueLanguage
dc.contributor.authorFreitas, Andreia-
dc.contributor.authorBarbosa, Jorge-
dc.contributor.authorRamos, Fernando-
dc.date.accessioned2014-12-02T16:47:02Z-
dc.date.available2014-12-02T16:47:02Z-
dc.date.issued2014-11-
dc.identifier.citationFREITAS, Andreia; BARBOSA, Jorge; RAMOS, Fernando - Multidetection of antibiotics in liver tissue by Ultra-High-Pressure-Liquid-Chromatography tandem Mass Spectrometry. "Journal of Chromatography B". ISSN 1570-0232. (2014)por
dc.identifier.issn1570-0232-
dc.identifier.urihttp://hdl.handle.net/10316/27752-
dc.description.abstractA multiresidue quantitative screening method covering 39 antibiotics from 7 different families by Ultra-High-Pressure-Liquid-Chromatography tandem Mass Spectrometry (UHPLC-MS/MS) is described. Sulfonamides, trimethoprim, tetracyclines, macrolides, quinolones, penicillins and chloramphenicol are simultaneously detected in liver tissue. A simple sample treatment method consisting of extraction with a mixture of acetonitrile and ethylenediaminetetraacetic acid (EDTA) followed by solid-phase extraction (SPE) with a hydrophilic-lipophilic balanced (HLB) cartridge was developed. The methodology was validated, in accordance with Decision 2002/657/EC, by evaluating the following required parameters: decision limit (CCα), detection capability (CCβ), specificity, repeatability and reproducibility. The precision, in terms of the relative standard deviation, was under 22% for all of the compounds, and the recoveries were between 80% and 110%. The CCα and CCβ were determined according to the maximum residue limit (MRL) or the minimum required performance limit (MRPL), when established.por
dc.language.isoengpor
dc.publisherElsevierpor
dc.rightsopenAccesspor
dc.subjectAntibioticspor
dc.subjectMulticlasspor
dc.subjectMultidetectionpor
dc.subjectUHPLC-MS/MSpor
dc.subjectLiverpor
dc.subjectValidationpor
dc.titleMultidetection of antibiotics in liver tissue by Ultra-High-Pressure-Liquid-Chromatography tandem Mass Spectrometrypor
dc.typearticlepor
degois.publication.titleJournal of Chromatography Bpor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1570023214006989por
dc.peerreviewedYespor
dc.identifier.doi10.1016/j.jchromb.2014.11.008-
item.grantfulltextopen-
item.fulltextCom Texto completo-
Appears in Collections:FFUC- Artigos em Revistas Internacionais
I&D CEFarmacêuticos - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais
Files in This Item:
File Description SizeFormat 
Multidetection of antibiotics in liver tissue by.pdf448.97 kBAdobe PDFView/Open
Show simple item record

SCOPUSTM   
Citations

6
checked on Apr 12, 2019

WEB OF SCIENCETM
Citations

7
checked on Jun 11, 2019

Page view(s)

167
checked on Jun 12, 2019

Download(s)

88
checked on Jun 12, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.